Graphene oxide coatings prevent Candida albicans biofilm formation with a controlled release of curcumin-loaded nanocomposites

Valentina Palmieri, Francesca Bugli, Margherita Cacaci, Giordano Perini, Flavio De Maio, Giovanni Delogu, Riccardo Torelli, Claudio Conti, Maurizio Sanguinetti, Marco De Spirito, Robertino Zanoni, Massimiliano Papi

Research output: Contribution to journalArticle

Abstract

Aim: Fabrication of graphene oxide (GO)-based medical devices coatings that limit adhesion of Candida albicans, a main issue of healthcare-associated infections. Methods: The GO composites noncovalently functionalized with curcumin (CU), a hydrophobic molecule with active antimicrobial action, polyethylene glycol (PEG) that hinders the absorption of biomolecules or a combination of CU and PEG (GO-CU-PEG) were drop-casted on surfaces and antifungal efficacy was assessed. Results: We demonstrate that GO-CU-PEG coatings can reduce fungal adhesion, proliferation and biofilm formation. Furthermore, in an aqueous environment, surfaces release curcumin-PEG nanocomposites that have a minimum inhibitory concentration of 9.25 μg/ml against C. albicans. Conclusion: Prevention of early cell adhesion and creation of a proximal environment unfavorable for growth make these GO-supported biomaterials attractive for innovative medical device manufacturing. </inline-graphic.

Original languageEnglish
Pages (from-to)2867-2879
Number of pages13
JournalNanomedicine
Volume13
Issue number22
DOIs
Publication statusPublished - Nov 1 2018

Keywords

  • coating
  • curcumin
  • graphene
  • immunology/infectious diseases
  • nanocomposites
  • PEGylation
  • preventive medicine
  • targeted therapy

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Materials Science(all)

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  • Cite this

    Palmieri, V., Bugli, F., Cacaci, M., Perini, G., De Maio, F., Delogu, G., Torelli, R., Conti, C., Sanguinetti, M., De Spirito, M., Zanoni, R., & Papi, M. (2018). Graphene oxide coatings prevent Candida albicans biofilm formation with a controlled release of curcumin-loaded nanocomposites. Nanomedicine, 13(22), 2867-2879. https://doi.org/10.2217/nnm-2018-0183