Graves' hyperthyroidism and ophthalmopathy associated with pemphigus vulgaris: Onset of thyroid autoimmune disease during chronic low-dose glucocorticoid therapy

L. Bartalena, F. Bogazzi, L. Chiovato, M. L. Tanda, E. Martino

Research output: Contribution to journalArticlepeer-review

Abstract

A 38-year-old caucasian woman developed typical Graves' hyperthyroidism and ophthalmopathy while being chronically treated for pemphigus vulgaris with low doses of glucocorticoids capable of effectively controlling skin disease, HLA typing showed positivity for DR3 and DR4, suggesting a genetic susceptibility for both Graves' disease and pemphigus vulgaris. The apparent contradiction whereby thyroid autoimmune disease flared up during therapy with glucocorticoids, known for their immunosuppressive effects, may be related to the dose of steroids. It is possible that high doses of glucocorticoids, commonly employed in the treatment of severe Graves' ophthalmopathy, might indeed suppress the disease, whereas the low doses used in this patient might precipitate or aggravate it.

Original languageEnglish
Pages (from-to)155-157
Number of pages3
JournalJournal of Endocrinological Investigation
Volume20
Issue number3
Publication statusPublished - Mar 1997

Keywords

  • Glucocorticoids
  • Graves' disease
  • Graves' ophthalmopathy
  • HLA
  • Immunosuppression
  • Pemphigus vulgaris
  • Thyroid autoimmunity

ASJC Scopus subject areas

  • Endocrinology

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