Graves' ophthalmopathy and atrophic thyroiditis: A case report

G. Tamagno, E. De Carlo, C. Betterle, G. Murialdo

Research output: Contribution to journalArticlepeer-review


Graves' ophthalmopathy (GO) - also known as thyroid-associated orbitopathy or ophthalmopathy - usually affects patients with Graves' disease. Antibodies stimulating the TSH receptor are thought to be involved in the pathogenesis of this important and disabling extra-thyroidal manifestation of Graves' disease. Less frequently, GO occurs in subjects who neither have nor have ever shown evidence of thyroid dysfunction ("euthyroid GO"), while the occurrence of GO in patients with autoimmune Hashimoto's thyroiditis is thought to be quite rare and has sporadically been reported. The late and abrupt occurrence of severe GO without hyperthyroidism in an 88-yr-old woman with primary myxedema due to atrophic thyroiditis must be considered as an exceptional event. In this patient, GO was combined with elevated titres of serum auto-antibodies directed against the TSH receptor, while serum levels of anti-thyroglobulin and thyroperoxidase antibodies were within the normal range or only occasionally slightly above the normal values.

Original languageEnglish
Pages (from-to)163-166
Number of pages4
JournalJournal of Endocrinological Investigation
Issue number2
Publication statusPublished - Feb 2004


  • Atrophic thyroiditis
  • Graves' ophthalmopathy
  • Thyroid autoimmune disease
  • TSH-receptor antibodies

ASJC Scopus subject areas

  • Endocrinology


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