Gray matter atrophy and disability progression in patients with early relapsing-remitting multiple sclerosis. A 5-year longitudinal study

Dana Horakova, Michael G. Dwyer, Eva Havrdova, Jennifer L. Cox, Ondrej Dolezal, Niels Bergsland, Brett Rimes, Zdeněk Seidl, Manuela Vaneckova, Robert Zivadinov

Research output: Contribution to journalArticlepeer-review

Abstract

We assessed the relationship between gray matter (GM) and white matter (WM) atrophy and clinical status in early relapsing-remitting multiple sclerosis (MS) patients over 5 years. A group of 181 patients who participated in the ASA (Avonex-Steroid-Azathioprine) study and had complete clinical and MRI assessments over 2 and 5 years was investigated. One hundred seventy (170) patients completed the 12-month follow-up, 147 the 24-month, 98 the 36-month, 65 the 48-month and 47 the 60-month. Changes in GM (GMV), WM (WMV) and peripheral GM (PGV) volumes, whole brain volume (percentage brain volume change PBVC), lateral ventricle volume (LVV), third ventricle width (3VW) and T2-lesion volume (T2-LV) were measured. Patients were assigned according to their clinical status to one of two groups: the Stable group, and the Reached Confirmed Sustained Progression (RCSP) group (24-week interval). At 0-6 months PBVC and GMV, at 0-12 months PBVC, GMV and T2-LV, at 0-24 months PBVC and GMV, at 0-36 months PBVC, GMV and T2-LV, and at 0-48 PBVC predicted the differences between the RCSP and Stable groups. PBVC and LVV showed the strongest ability to differentiate patients who presented 0 or ≥ 3 relapses in the Stable group. Decline in PBVC and GMV were predictive markers of disability deterioration. Correlation of T2-LV with clinical status was weaker and decreased over time. Higher number of relapses was associated with faster decline in whole brain volume.

Original languageEnglish
Pages (from-to)112-119
Number of pages8
JournalJournal of the Neurological Sciences
Volume282
Issue number1-2
DOIs
Publication statusPublished - Jul 15 2009

Keywords

  • Brain atrophy
  • Disability
  • Gray matter
  • MRI
  • Multiple sclerosis
  • Relapse rate
  • White matter

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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