Gray matter atrophy cannot be fully explained by white matter damage in patients with MS

Jian Zhang, Antonio Giorgio, Claudia Vinciguerra, Maria Laura Stromillo, Marco Battaglini, Marzia Mortilla, Riccardo Tappa Brocci, Emilio Portaccio, Maria Pia Amato, Nicola De Stefano

Research output: Contribution to journalArticle

Abstract

Background: Source-based morphometry (SBM) was recently used for non-random “patterns” of gray matter (GM) atrophy or white matter (WM) microstructural damage. Objective: To assess whether and to what extent such patterns may be inter-related in MS. Methods: SBM was applied to images of GM concentration and fractional anisotropy (FA) in MS patients (n = 41, median EDSS = 1) and normal controls (NC, n = 28). The same procedure was repeated on an independent and similar data set (39 MS patients and 13 NC). Results: We found in MS patterns of GM atrophy and reduced FA (p < 0.05, corrected). Deep GM atrophy was mostly (70%) explained by lesion load in projection tracts and lower FA in posterior corona radiata and thalamic radiation. By contrast, sensorimotor and posterior cortex atrophy was less (50%) dependent from WM damage. All patterns correlated with EDSS (r from −0.33 to −0.56, p < 0.03) while the only cognition-related correlation was between posterior GM atrophy pattern and processing speed (r = 0.45, p = 0.014). Reliability analysis showed similar results. Conclusion: In relatively early MS, we found a close link between deep GM atrophy pattern and WM damage while sensorimotor and posterior cortex patterns were partially independent from WM damage and perhaps related to primary mechanisms. Patterns were clinically relevant.

Original languageEnglish
JournalMultiple Sclerosis Journal
DOIs
Publication statusAccepted/In press - Jan 1 2020

Keywords

  • atrophy
  • connectivity
  • DTI
  • lesions
  • MRI
  • Multiple sclerosis

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Gray matter atrophy cannot be fully explained by white matter damage in patients with MS'. Together they form a unique fingerprint.

  • Cite this

    Zhang, J., Giorgio, A., Vinciguerra, C., Stromillo, M. L., Battaglini, M., Mortilla, M., Tappa Brocci, R., Portaccio, E., Amato, M. P., & De Stefano, N. (Accepted/In press). Gray matter atrophy cannot be fully explained by white matter damage in patients with MS. Multiple Sclerosis Journal. https://doi.org/10.1177/1352458519900972