Gray matter differences between affective and non-affective first episode psychosis

A review of Magnetic Resonance Imaging studies

A. Calvo, G. Delvecchio, A. C. Altamura, J. C. Soares, P. Brambilla

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Non-affective and affective psychoses are very common mental disorders. However, their neurobiological underpinnings are still poorly understood. Therefore, the goal of the present review was to evaluate structural Magnetic Resonance Imaging (MRI) studies exploring brain deficits in both non-affective (NA-FEP) and affective first episode psychosis (A-FEP). Methods: A bibliographic search on PUBMED of all MRI studies exploring gray matter (GM) differences between NA-FEP and A-FEP was conducted. Results: Overall, the results from the available evidence showed that the two diagnostic groups share common GM alterations in fronto-temporal regions and anterior cingulate cortex. In contrast, unique GM deficits have also been observed, with reductions in amygdala for A-FEP and in hippocampus and insula for NA-FEP. Limitations: Few small MRI studies with heterogeneous methodology. Conclusions: Although the evidences are far to be conclusive, they suggest the presence of common and distinct pattern of GM alterations in NA-FEP and A-FEP. Future larger longitudinal studies are needed to further characterize specific neural biomarkers in homogenous NA-FEP and A-FEP samples.

Original languageEnglish
Pages (from-to)564-574
Number of pages11
JournalJournal of Affective Disorders
Volume243
DOIs
Publication statusPublished - 2019

Fingerprint

Polytetrafluoroethylene
Psychotic Disorders
Magnetic Resonance Imaging
Gray Matter
Psychotic Affective Disorders
Gyrus Cinguli
Temporal Lobe
Amygdala
Mental Disorders
Longitudinal Studies
Hippocampus
Biomarkers
Brain

Keywords

  • Affective
  • First episode psychosis
  • Gray matter
  • Magnetic Resonance Imaging
  • Non-affective

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health

Cite this

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title = "Gray matter differences between affective and non-affective first episode psychosis: A review of Magnetic Resonance Imaging studies",
abstract = "Background: Non-affective and affective psychoses are very common mental disorders. However, their neurobiological underpinnings are still poorly understood. Therefore, the goal of the present review was to evaluate structural Magnetic Resonance Imaging (MRI) studies exploring brain deficits in both non-affective (NA-FEP) and affective first episode psychosis (A-FEP). Methods: A bibliographic search on PUBMED of all MRI studies exploring gray matter (GM) differences between NA-FEP and A-FEP was conducted. Results: Overall, the results from the available evidence showed that the two diagnostic groups share common GM alterations in fronto-temporal regions and anterior cingulate cortex. In contrast, unique GM deficits have also been observed, with reductions in amygdala for A-FEP and in hippocampus and insula for NA-FEP. Limitations: Few small MRI studies with heterogeneous methodology. Conclusions: Although the evidences are far to be conclusive, they suggest the presence of common and distinct pattern of GM alterations in NA-FEP and A-FEP. Future larger longitudinal studies are needed to further characterize specific neural biomarkers in homogenous NA-FEP and A-FEP samples.",
keywords = "Affective, First episode psychosis, Gray matter, Magnetic Resonance Imaging, Non-affective",
author = "A. Calvo and G. Delvecchio and Altamura, {A. C.} and Soares, {J. C.} and P. Brambilla",
year = "2019",
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language = "English",
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journal = "Journal of Affective Disorders",
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T1 - Gray matter differences between affective and non-affective first episode psychosis

T2 - A review of Magnetic Resonance Imaging studies

AU - Calvo, A.

AU - Delvecchio, G.

AU - Altamura, A. C.

AU - Soares, J. C.

AU - Brambilla, P.

PY - 2019

Y1 - 2019

N2 - Background: Non-affective and affective psychoses are very common mental disorders. However, their neurobiological underpinnings are still poorly understood. Therefore, the goal of the present review was to evaluate structural Magnetic Resonance Imaging (MRI) studies exploring brain deficits in both non-affective (NA-FEP) and affective first episode psychosis (A-FEP). Methods: A bibliographic search on PUBMED of all MRI studies exploring gray matter (GM) differences between NA-FEP and A-FEP was conducted. Results: Overall, the results from the available evidence showed that the two diagnostic groups share common GM alterations in fronto-temporal regions and anterior cingulate cortex. In contrast, unique GM deficits have also been observed, with reductions in amygdala for A-FEP and in hippocampus and insula for NA-FEP. Limitations: Few small MRI studies with heterogeneous methodology. Conclusions: Although the evidences are far to be conclusive, they suggest the presence of common and distinct pattern of GM alterations in NA-FEP and A-FEP. Future larger longitudinal studies are needed to further characterize specific neural biomarkers in homogenous NA-FEP and A-FEP samples.

AB - Background: Non-affective and affective psychoses are very common mental disorders. However, their neurobiological underpinnings are still poorly understood. Therefore, the goal of the present review was to evaluate structural Magnetic Resonance Imaging (MRI) studies exploring brain deficits in both non-affective (NA-FEP) and affective first episode psychosis (A-FEP). Methods: A bibliographic search on PUBMED of all MRI studies exploring gray matter (GM) differences between NA-FEP and A-FEP was conducted. Results: Overall, the results from the available evidence showed that the two diagnostic groups share common GM alterations in fronto-temporal regions and anterior cingulate cortex. In contrast, unique GM deficits have also been observed, with reductions in amygdala for A-FEP and in hippocampus and insula for NA-FEP. Limitations: Few small MRI studies with heterogeneous methodology. Conclusions: Although the evidences are far to be conclusive, they suggest the presence of common and distinct pattern of GM alterations in NA-FEP and A-FEP. Future larger longitudinal studies are needed to further characterize specific neural biomarkers in homogenous NA-FEP and A-FEP samples.

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