Gray matter SWI-filtered phase and atrophy are linked to Disability in MS

Jesper Hagemeier, Bianca Weinstock-Guttman, Mari Heininen-Brown, Guy U. Poloni, Niels Bergsland, Claudiu Schirda, Christopher R. Magnano, Cheryl Kennedy, Ellen Carl, Michael G. Dwyer, Alireza Minagar, Robert Zivadinov

Research output: Contribution to journalArticlepeer-review


The association between clinical outcomes and abnormal susceptibility- weighted imaging (SWI)-filtered phase, indicative of increased iron content, as well as atrophy, was investigated in the subcortical deep-gray matter (SDGM) of multiple sclerosis (MS) patients. 149 relapsing-remitting (RR) and 61 secondary-progressive (SP) MS patients underwent SWI on a 3T scanner. Mean phase of the abnormal phase tissue (MP-APT) and normalized volumes were determined for the total and region-specific SDGM structures. In an age- and genderadjusted regression model, total SDGM volume was the strongest predictor of Expanded Disability Status Scale (EDSS) (beta = -.224, p

Original languageEnglish
Pages (from-to)525-532
Number of pages8
JournalFrontiers in Bioscience - Elite
Volume5 E
Issue number2
Publication statusPublished - Jan 1 2013


  • Abnormal phase
  • Brain atrophy
  • Disability
  • Iron deposition
  • Multiple sclerosis
  • Susceptibility-weighted imaging filtered phase

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)


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