Gray matter volumes may predict the clinical response to paliperidone palmitate long-acting in acute psychosis: A pilot longitudinal neuroimaging study

A Carlo Altamura, Giuseppe Delvecchio, Silvia Paletta, Chiara Di Pace, Alessandra Reggiori, Alessio Fiorentini, M Donatella Mirabile, Riccardo A Paoli, Claudia Cinnante, Fabio Triulzi, Massimo C Mauri, Paolo Brambilla

Research output: Contribution to journalArticle

Abstract

In schizophrenia, paliperidone palmitate (PP) long acting injectable (LAI) has been reported to sustain plasma concentrations and improve clinical symptoms. Moreover, it has also been demonstrated the important role of total gray matter (GM) volumes in predicting the clinical outcome. However, no studies investigating the association between PP-LAI treatment and brain morphometry has been published so far. Therefore, the main aim of our 24 weeks prospective observational exploratory study was to investigate the relation between brain anatomy and clinical outcome in seven patients with acute psychosis treated with PP-LAI. At baseline and every month (from T0 to T6) patients were clinically evaluated with the Brief Psychiatric Rating Scale (BPRS). 3T Magnetic Resonance Imaging at baseline was acquired and total GM and intracranial volumes were extracted to explore their predictive values on BPRS scores. After 24 weeks of treatment with PP-LAI, patients showed statistically significant improvements in BPRS scores. Moreover, subjects with higher total GM volumes had a significantly higher BPRS improvement at 24 weeks compared to patients with lower total GM volumes. Our findings confirm the effectiveness of PP-LAI in treating acute psychosis and suggest that greater GM volumes predict drug response, potentially supporting a favorable prognosis.

Original languageEnglish
Pages (from-to)80-84
Number of pages5
JournalPsychiatry Research
Volume261
DOIs
Publication statusPublished - Mar 30 2017

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Brief Psychiatric Rating Scale
Neuroimaging
Psychotic Disorders
Longitudinal Studies
Injections
Brain
Observational Studies
Anatomy
Schizophrenia
Magnetic Resonance Imaging
Gray Matter
Paliperidone Palmitate
Therapeutics
Pharmaceutical Preparations

Keywords

  • Adult
  • Antipsychotic Agents
  • Brief Psychiatric Rating Scale
  • Female
  • Gray Matter
  • Humans
  • Longitudinal Studies
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Neuroimaging
  • Organ Size
  • Paliperidone Palmitate
  • Pilot Projects
  • Predictive Value of Tests
  • Prospective Studies
  • Psychotic Disorders
  • Treatment Outcome
  • Young Adult
  • Journal Article

Cite this

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title = "Gray matter volumes may predict the clinical response to paliperidone palmitate long-acting in acute psychosis: A pilot longitudinal neuroimaging study",
abstract = "In schizophrenia, paliperidone palmitate (PP) long acting injectable (LAI) has been reported to sustain plasma concentrations and improve clinical symptoms. Moreover, it has also been demonstrated the important role of total gray matter (GM) volumes in predicting the clinical outcome. However, no studies investigating the association between PP-LAI treatment and brain morphometry has been published so far. Therefore, the main aim of our 24 weeks prospective observational exploratory study was to investigate the relation between brain anatomy and clinical outcome in seven patients with acute psychosis treated with PP-LAI. At baseline and every month (from T0 to T6) patients were clinically evaluated with the Brief Psychiatric Rating Scale (BPRS). 3T Magnetic Resonance Imaging at baseline was acquired and total GM and intracranial volumes were extracted to explore their predictive values on BPRS scores. After 24 weeks of treatment with PP-LAI, patients showed statistically significant improvements in BPRS scores. Moreover, subjects with higher total GM volumes had a significantly higher BPRS improvement at 24 weeks compared to patients with lower total GM volumes. Our findings confirm the effectiveness of PP-LAI in treating acute psychosis and suggest that greater GM volumes predict drug response, potentially supporting a favorable prognosis.",
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author = "Altamura, {A Carlo} and Giuseppe Delvecchio and Silvia Paletta and {Di Pace}, Chiara and Alessandra Reggiori and Alessio Fiorentini and Mirabile, {M Donatella} and Paoli, {Riccardo A} and Claudia Cinnante and Fabio Triulzi and Mauri, {Massimo C} and Paolo Brambilla",
note = "Copyright {\circledC} 2017 Elsevier Ireland Ltd. All rights reserved.",
year = "2017",
month = "3",
day = "30",
doi = "10.1016/j.pscychresns.2017.01.008",
language = "English",
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TY - JOUR

T1 - Gray matter volumes may predict the clinical response to paliperidone palmitate long-acting in acute psychosis

T2 - A pilot longitudinal neuroimaging study

AU - Altamura, A Carlo

AU - Delvecchio, Giuseppe

AU - Paletta, Silvia

AU - Di Pace, Chiara

AU - Reggiori, Alessandra

AU - Fiorentini, Alessio

AU - Mirabile, M Donatella

AU - Paoli, Riccardo A

AU - Cinnante, Claudia

AU - Triulzi, Fabio

AU - Mauri, Massimo C

AU - Brambilla, Paolo

N1 - Copyright © 2017 Elsevier Ireland Ltd. All rights reserved.

PY - 2017/3/30

Y1 - 2017/3/30

N2 - In schizophrenia, paliperidone palmitate (PP) long acting injectable (LAI) has been reported to sustain plasma concentrations and improve clinical symptoms. Moreover, it has also been demonstrated the important role of total gray matter (GM) volumes in predicting the clinical outcome. However, no studies investigating the association between PP-LAI treatment and brain morphometry has been published so far. Therefore, the main aim of our 24 weeks prospective observational exploratory study was to investigate the relation between brain anatomy and clinical outcome in seven patients with acute psychosis treated with PP-LAI. At baseline and every month (from T0 to T6) patients were clinically evaluated with the Brief Psychiatric Rating Scale (BPRS). 3T Magnetic Resonance Imaging at baseline was acquired and total GM and intracranial volumes were extracted to explore their predictive values on BPRS scores. After 24 weeks of treatment with PP-LAI, patients showed statistically significant improvements in BPRS scores. Moreover, subjects with higher total GM volumes had a significantly higher BPRS improvement at 24 weeks compared to patients with lower total GM volumes. Our findings confirm the effectiveness of PP-LAI in treating acute psychosis and suggest that greater GM volumes predict drug response, potentially supporting a favorable prognosis.

AB - In schizophrenia, paliperidone palmitate (PP) long acting injectable (LAI) has been reported to sustain plasma concentrations and improve clinical symptoms. Moreover, it has also been demonstrated the important role of total gray matter (GM) volumes in predicting the clinical outcome. However, no studies investigating the association between PP-LAI treatment and brain morphometry has been published so far. Therefore, the main aim of our 24 weeks prospective observational exploratory study was to investigate the relation between brain anatomy and clinical outcome in seven patients with acute psychosis treated with PP-LAI. At baseline and every month (from T0 to T6) patients were clinically evaluated with the Brief Psychiatric Rating Scale (BPRS). 3T Magnetic Resonance Imaging at baseline was acquired and total GM and intracranial volumes were extracted to explore their predictive values on BPRS scores. After 24 weeks of treatment with PP-LAI, patients showed statistically significant improvements in BPRS scores. Moreover, subjects with higher total GM volumes had a significantly higher BPRS improvement at 24 weeks compared to patients with lower total GM volumes. Our findings confirm the effectiveness of PP-LAI in treating acute psychosis and suggest that greater GM volumes predict drug response, potentially supporting a favorable prognosis.

KW - Adult

KW - Antipsychotic Agents

KW - Brief Psychiatric Rating Scale

KW - Female

KW - Gray Matter

KW - Humans

KW - Longitudinal Studies

KW - Magnetic Resonance Imaging

KW - Male

KW - Middle Aged

KW - Neuroimaging

KW - Organ Size

KW - Paliperidone Palmitate

KW - Pilot Projects

KW - Predictive Value of Tests

KW - Prospective Studies

KW - Psychotic Disorders

KW - Treatment Outcome

KW - Young Adult

KW - Journal Article

U2 - 10.1016/j.pscychresns.2017.01.008

DO - 10.1016/j.pscychresns.2017.01.008

M3 - Article

C2 - 28161644

VL - 261

SP - 80

EP - 84

JO - Psychiatry Research

JF - Psychiatry Research

SN - 0165-1781

ER -