Green tea polyphenol extract attenuates colon injury induced by experimental colitis

Emanuela Mazzon, Carmelo Muià, Rosanna Di Paola, Tiziana Genovese, Marta Menegazzi, Angelina De Sarro, Hisanori Suzuki, Salvatore Cuzzocrea

Research output: Contribution to journalArticlepeer-review

Abstract

Inflammatory bowel disease (IBD) is characterised by oxidative and nitrosative stress, leukocyte infiltration, and up-regulation of intercellular adhesion molecule 1 (ICAM-1) expression in the colon. The aim of the present study was to examine the effects of green tea extract in rats subjected to experimental colitis induced by intracolonic instillation of dinitrobenzene sulphonic acid (DNBS). At 4 days after DNBS administration the rats were sacrificed. Treatment with green tea extract significantly attenuated diarrhoea and loss of body weight. This was associated with a remarkable amelioration of the disruption of the colonic architecture, significant reduction of colonic myeloperoxidase (MPO) and tumor necrosis factor-α (TNF-α) production. Green tea extract also reduced the appearance of nitrotyrosine immunoreactivity in the colon and reduced the up-regulation of ICAM-1.

Original languageEnglish
Pages (from-to)1017-1025
Number of pages9
JournalFree Radical Research
Volume39
Issue number9
DOIs
Publication statusPublished - Sep 2005

Keywords

  • Colitis
  • Free radical
  • Green tea extract
  • Inflammatory infiltration and ICAM-1

ASJC Scopus subject areas

  • Biochemistry

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