Green tea polyphenol extract attenuates colon injury induced by experimental colitis

Emanuela Mazzon; Carmelo Muià; Rosanna Di Paola; Tiziana Genovese; Marta Menegazzi; Angelina De Sarro; Hisanori Suzuki; Salvatore Cuzzocrea

doi:10.1080/10715760500197177

Green tea polyphenol extract attenuates colon injury induced by experimental colitis

Emanuela Mazzon, Carmelo Muià, Rosanna Di Paola, Tiziana Genovese, Marta Menegazzi, Angelina De Sarro, Hisanori Suzuki, Salvatore Cuzzocrea

IRCCS Centro Neurolesi "Bonino Pulejo"

Research output: Contribution to journal › Article › peer-review

Abstract

Inflammatory bowel disease (IBD) is characterised by oxidative and nitrosative stress, leukocyte infiltration, and up-regulation of intercellular adhesion molecule 1 (ICAM-1) expression in the colon. The aim of the present study was to examine the effects of green tea extract in rats subjected to experimental colitis induced by intracolonic instillation of dinitrobenzene sulphonic acid (DNBS). At 4 days after DNBS administration the rats were sacrificed. Treatment with green tea extract significantly attenuated diarrhoea and loss of body weight. This was associated with a remarkable amelioration of the disruption of the colonic architecture, significant reduction of colonic myeloperoxidase (MPO) and tumor necrosis factor-α (TNF-α) production. Green tea extract also reduced the appearance of nitrotyrosine immunoreactivity in the colon and reduced the up-regulation of ICAM-1.

Original language	English
Pages (from-to)	1017-1025
Number of pages	9
Journal	Free Radical Research
Volume	39
Issue number	9
DOIs	https://doi.org/10.1080/10715760500197177
Publication status	Published - Sep 2005

Keywords

Colitis
Free radical
Green tea extract
Inflammatory infiltration and ICAM-1

ASJC Scopus subject areas

Biochemistry

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10.1080/10715760500197177

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Green tea polyphenol extract attenuates colon injury induced by experimental colitis. / Mazzon, Emanuela; Muià, Carmelo; Di Paola, Rosanna; Genovese, Tiziana; Menegazzi, Marta; De Sarro, Angelina; Suzuki, Hisanori; Cuzzocrea, Salvatore.

In: Free Radical Research, Vol. 39, No. 9, 09.2005, p. 1017-1025.

Research output: Contribution to journal › Article › peer-review

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abstract = "Inflammatory bowel disease (IBD) is characterised by oxidative and nitrosative stress, leukocyte infiltration, and up-regulation of intercellular adhesion molecule 1 (ICAM-1) expression in the colon. The aim of the present study was to examine the effects of green tea extract in rats subjected to experimental colitis induced by intracolonic instillation of dinitrobenzene sulphonic acid (DNBS). At 4 days after DNBS administration the rats were sacrificed. Treatment with green tea extract significantly attenuated diarrhoea and loss of body weight. This was associated with a remarkable amelioration of the disruption of the colonic architecture, significant reduction of colonic myeloperoxidase (MPO) and tumor necrosis factor-α (TNF-α) production. Green tea extract also reduced the appearance of nitrotyrosine immunoreactivity in the colon and reduced the up-regulation of ICAM-1.",

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AU - Menegazzi, Marta

AU - De Sarro, Angelina

AU - Suzuki, Hisanori

AU - Cuzzocrea, Salvatore

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N2 - Inflammatory bowel disease (IBD) is characterised by oxidative and nitrosative stress, leukocyte infiltration, and up-regulation of intercellular adhesion molecule 1 (ICAM-1) expression in the colon. The aim of the present study was to examine the effects of green tea extract in rats subjected to experimental colitis induced by intracolonic instillation of dinitrobenzene sulphonic acid (DNBS). At 4 days after DNBS administration the rats were sacrificed. Treatment with green tea extract significantly attenuated diarrhoea and loss of body weight. This was associated with a remarkable amelioration of the disruption of the colonic architecture, significant reduction of colonic myeloperoxidase (MPO) and tumor necrosis factor-α (TNF-α) production. Green tea extract also reduced the appearance of nitrotyrosine immunoreactivity in the colon and reduced the up-regulation of ICAM-1.

AB - Inflammatory bowel disease (IBD) is characterised by oxidative and nitrosative stress, leukocyte infiltration, and up-regulation of intercellular adhesion molecule 1 (ICAM-1) expression in the colon. The aim of the present study was to examine the effects of green tea extract in rats subjected to experimental colitis induced by intracolonic instillation of dinitrobenzene sulphonic acid (DNBS). At 4 days after DNBS administration the rats were sacrificed. Treatment with green tea extract significantly attenuated diarrhoea and loss of body weight. This was associated with a remarkable amelioration of the disruption of the colonic architecture, significant reduction of colonic myeloperoxidase (MPO) and tumor necrosis factor-α (TNF-α) production. Green tea extract also reduced the appearance of nitrotyrosine immunoreactivity in the colon and reduced the up-regulation of ICAM-1.

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Green tea polyphenol extract attenuates colon injury induced by experimental colitis

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Keywords

ASJC Scopus subject areas

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