Grey matter damage in progressive multiple sclerosis versus amyotrophic lateral sclerosis: a voxel-based morphometry MRI study

Eleonora Tavazzi, Maria Marcella Laganà, Niels Bergsland, Paola Tortorella, Giovanna Pinardi, Christian Lunetta, Massimo Corbo, Marco Rovaris

Research output: Contribution to journalArticle


Primary progressive multiple sclerosis (PPMS) and amyotrophic lateral sclerosis (ALS) seem to share some clinical and pathological features. MRI studies revealed the presence of grey matter (GM) atrophy in both diseases, but no comparative data are available. The objective was to compare the regional patterns of GM tissue loss in PPMS and ALS with voxel-based morphometry (VBM). Eighteen PPMS patients, 20 ALS patients, and 31 healthy controls (HC) were studied with a 1.5 Tesla scanner. VBM was performed to assess volumetric GM differences with age and sex as covariates. Threshold-free cluster enhancement analysis was used to obtain significant clusters. Group comparisons were tested with family-wise error correction for multiple comparisons (p 

Original languageEnglish
Pages (from-to)371-377
Number of pages7
JournalNeurological Sciences
Issue number3
Publication statusPublished - 2015



  • Amyotrophic lateral sclerosis
  • Grey matter
  • MRI
  • Multiple sclerosis
  • Voxel-based morphometry

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Dermatology
  • Medicine(all)

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