TY - JOUR
T1 - Grey matter damage in progressive multiple sclerosis versus amyotrophic lateral sclerosis
T2 - a voxel-based morphometry MRI study
AU - Tavazzi, Eleonora
AU - Laganà, Maria Marcella
AU - Bergsland, Niels
AU - Tortorella, Paola
AU - Pinardi, Giovanna
AU - Lunetta, Christian
AU - Corbo, Massimo
AU - Rovaris, Marco
PY - 2015
Y1 - 2015
N2 - Primary progressive multiple sclerosis (PPMS) and amyotrophic lateral sclerosis (ALS) seem to share some clinical and pathological features. MRI studies revealed the presence of grey matter (GM) atrophy in both diseases, but no comparative data are available. The objective was to compare the regional patterns of GM tissue loss in PPMS and ALS with voxel-based morphometry (VBM). Eighteen PPMS patients, 20 ALS patients, and 31 healthy controls (HC) were studied with a 1.5 Tesla scanner. VBM was performed to assess volumetric GM differences with age and sex as covariates. Threshold-free cluster enhancement analysis was used to obtain significant clusters. Group comparisons were tested with family-wise error correction for multiple comparisons (p
AB - Primary progressive multiple sclerosis (PPMS) and amyotrophic lateral sclerosis (ALS) seem to share some clinical and pathological features. MRI studies revealed the presence of grey matter (GM) atrophy in both diseases, but no comparative data are available. The objective was to compare the regional patterns of GM tissue loss in PPMS and ALS with voxel-based morphometry (VBM). Eighteen PPMS patients, 20 ALS patients, and 31 healthy controls (HC) were studied with a 1.5 Tesla scanner. VBM was performed to assess volumetric GM differences with age and sex as covariates. Threshold-free cluster enhancement analysis was used to obtain significant clusters. Group comparisons were tested with family-wise error correction for multiple comparisons (p
KW - Amyotrophic lateral sclerosis
KW - Grey matter
KW - MRI
KW - Multiple sclerosis
KW - Voxel-based morphometry
UR - http://www.scopus.com/inward/record.url?scp=84923818901&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84923818901&partnerID=8YFLogxK
U2 - 10.1007/s10072-014-1954-7
DO - 10.1007/s10072-014-1954-7
M3 - Article
C2 - 25228014
AN - SCOPUS:84923818901
VL - 36
SP - 371
EP - 377
JO - Neurological Sciences
JF - Neurological Sciences
SN - 1590-1874
IS - 3
ER -