Grey matter volume alterations in CADASIL: A voxel-based morphometry study

Maria Camilla Rossi Espagnet, Andrea Romano, Filippo Carducci, Luigi Fausto Calabria, Martina Fiorillo, Francesco Orzi, Alessandro Bozzao

Research output: Contribution to journalArticlepeer-review


CADASIL is a hereditary disease characterized by cerebral subcortical microangiopathy leading to early onset cerebral strokes and progressive severe cognitive impairment. Until now, only few studies have investigated the extent and localization of grey matter (GM) involvement. The purpose of our study was to evaluate GM volume alterations in CADASIL patients compared to healthy subjects. We also looked for correlations between global and regional white matter (WM) lesion load and GM volume alterations. 14 genetically proved CADASIL patients and 12 healthy subjects were enrolled in our study. Brain MRI (1.5 T) was acquired in all subjects. Optimized-voxel based morphometry method was applied for the comparison of brain volumes between CADASIL patients and controls. Global and lobar WM lesion loads were calculated for each patient and used as covariate-of-interest for regression analyses with SPM-8. Compared to controls, patients showed GM volume reductions in bilateral temporal lobes (p

Original languageEnglish
Pages (from-to)231-238
Number of pages8
JournalJournal of Headache and Pain
Issue number3
Publication statusPublished - Apr 2012


  • Dementia
  • VBM

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Clinical Neurology


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