Grey-scale analysis allows a quantitative evaluation of thyroid echogenicity in the patients with Hashimoto's thyroiditis

Gherardo Mazziotti, Francesca Sorvillo, Sergio Iorio, Antonella Carbone, Antonio Romeo, Marco Piscopo, Salvatore Capuano, Ermanno Capuano, Giovanni Amato, Carlo Carella

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVE: In the present study we have performed a grey-scale quantitative analysis of thyroid echogenicity in the patients affected by Hashimoto's thyroiditis (HT), obtaining a numerical estimate of the degree of hypoecogenicity associated with the appearance of thyroid dysfunction. MATERIALS AND METHODS: The study group included 89 patients with serum positivity for thyroglobulin (TgAb) and/or peroxidase (TPOAb) antibodies. Ultrasound (US) evaluation of thyroid gland and biochemical assay of serum thyrotropin (TSH), free-thyroxine (FT4) and free-triiodiothyronyne (FT3) were performed in all patients, and in 40 healthy subjects enrolled as control group. Thyroid echogenicity was compared with that of the surrounding neck muscles, using the grey-scale histogram analysis. The echogenicity was expressed in grey-scales (GWE). RESULTS: In HT patients, the mean of thyroid echogenicity was lower when compared to the normal thyroid (61.9±8.3 GWE vs. 71.9±3.1 GWE; P=0.01). In all HT patients the lowest limit of thyroid echo distribution was in the echogenicity range of the surrounding muscle, the overlapping ranging between 3.4% and 95.0% (mean±SD 48.4±20.9%). The extension of like-muscle hypoechogenicity into the thyroid gland was significantly correlated with serum TSH values (r=0.37; P

Original languageEnglish
Pages (from-to)223-229
Number of pages7
JournalClinical Endocrinology
Volume59
Issue number2
DOIs
Publication statusPublished - Aug 1 2003

ASJC Scopus subject areas

  • Endocrinology

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