GRO-α/CXCR2 system and ADAM17 correlated expression in Sjögren's syndrome

Sabrina Lisi, Margherita Sisto, Dario Domenico Lofrumento, Massimo D'Amore, Raffaella De Lucro, Domenico Ribatti

Research output: Contribution to journalArticle

Abstract

The chemokine GRO-α and its receptor CXCR2 are associated with the chronic inflammation in Sjögren's syndrome (SS). To better understand the molecular mechanisms by which the GRO-α/CXCR2 system is involved in the SS inflammatory condition, our studies were designed to clarify the role of ADAM17 activation in the modulation of the GRO-α/CXCR2 chemokine system in epithelial cells (SGEC) from SS salivary glands. The CXCR2 overexpression observed in SS SGEC was dramatically decreased by ADAM17 inhibitor TAPI-1. In addition, comparing the expression levels of ADAM17 in healthy SGEC in presence or not of GRO-α treatment, we observed that GRO-α dose-dependently influences ADAM17 activation, an effect that was inhibited by blocking the interaction of GRO-α with its CXCR2 receptor. Our data show for the first time that ADAM17 has an important role in GRO-α/CXCR2 system activity regulation, suggesting that regulating CXCR2/ADAM17 interaction could be an attractive therapeutic target in SS.

Original languageEnglish
Pages (from-to)759-766
Number of pages8
JournalInflammation
Volume36
Issue number3
DOIs
Publication statusPublished - Jun 2013

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Keywords

  • ADAM 17
  • CXCR2
  • GRO-α
  • sjögren's syndrome
  • TAPI-1

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Lisi, S., Sisto, M., Lofrumento, D. D., D'Amore, M., De Lucro, R., & Ribatti, D. (2013). GRO-α/CXCR2 system and ADAM17 correlated expression in Sjögren's syndrome. Inflammation, 36(3), 759-766. https://doi.org/10.1007/s10753-013-9602-6