Group A rotavirus genotypes in hospital-acquired gastroenteritis in Italy, 2012-14

RotaNet–Italy Study Group

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Group A rotaviruses (RVA) are the leading cause of acute gastroenteritis (AGE) in young (aged <5 years) children, causing ∼250,000 deaths worldwide, mostly in developing countries. Differences on nucleotide sequences of VP7 (G-type) and VP4 (P-type) genes are the basis for the binary RVA nomenclature. Although at least 32 G-types and 47 P-types of rotavirus are presently known, most RVA infections in humans worldwide are related to five major G/P combinations: G1P[8], G2P[4], G3P[8], G4P[8], and G9P[8].

AIM: To provide the hospitals of the Italian surveillance network with update information on RVA AGE.

METHODS: During RVA gastroenteritis surveillance in Italy in 2012-14, a total of 2341 RVA-positive faecal samples were collected from children hospitalized with AGE, and RVA strains were genotyped following standard EuroRotaNet protocols.

FINDINGS: Most strains analysed belonged to the five major human genotypes and 118 out of 2341 (5.0%) were reported to be hospital-acquired. Comparison of the distributions of the RVA genotypes circulating in the community or associated with nosocomial infections showed a different distribution of genotypes circulating inside the hospital wards, with respect to those observed in the community. G1P[8] and G9P[8] RVA strains were detected frequently, whereas G12P[8] caused a single large nosocomial outbreak.

CONCLUSION: The information from this study will be useful to implement guidelines for preventing RVA AGE and optimizing the management of patients in hospital wards.

Original languageEnglish
Pages (from-to)262-267
Number of pages6
JournalJournal of Hospital Infection
Volume96
Issue number3
DOIs
Publication statusPublished - Jul 2017

Keywords

  • Child, Preschool
  • Cross Infection/epidemiology
  • Female
  • Gastroenteritis/epidemiology
  • Genotype
  • Humans
  • Infant
  • Infant, Newborn
  • Italy/epidemiology
  • Male
  • Pilot Projects
  • Rotavirus/classification
  • Rotavirus Infections/epidemiology

Fingerprint Dive into the research topics of 'Group A rotavirus genotypes in hospital-acquired gastroenteritis in Italy, 2012-14'. Together they form a unique fingerprint.

  • Cite this