Group a streptococcal genotypes from pediatric throat isolates in rome, Italy

G. Dicuonzo, G. Gherardi, G. Lorino, S. Angeletti, M. De Cesaris, E. Fiscarelli, D. E. Bessen, B. Beall

Research output: Contribution to journalArticlepeer-review


In a study assessing genetic diversity, 114 group A streptococcus (GAS) isolates were recovered from pediatric pharyngitis patients in Rome, Italy. These isolates comprised 22 different M protein gene (emm) sequence types, 14 of which were associated with a distinct serum opacity factor/fibronectin binding protein gene (sof) sequence type. Isolates with the same emm gene sequence type generally shared a highly conserved chromosomal macrorestriction profile. In three instances, isolates with dissimilar macrorestriction profiles had identical emm types; in each of these cases multilocus sequence typing revealed that isolates with the same emm type were clones having the same allelic profiles. Ninety-eight percent of the pharyngeal isolates had emm types previously found to be highly associated with mga locus gene patterns commonly found in pharyngeal GAS isolates.

Original languageEnglish
Pages (from-to)1687-1690
Number of pages4
JournalJournal of Clinical Microbiology
Issue number5
Publication statusPublished - 2001

ASJC Scopus subject areas

  • Microbiology (medical)
  • Microbiology


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