TY - JOUR
T1 - Group I metabotropic glutamate receptors
T2 - A role in neurodevelopmental disorders?
AU - Catania, Maria Vincenza
AU - D'Antoni, Simona
AU - Bonaccorso, Carmela Maria
AU - Aronica, Eleonora
AU - Bear, Mark F.
AU - Nicoletti, Ferdinando
PY - 2007/6
Y1 - 2007/6
N2 - Group I metabotropic glutamate receptors (mGlu1 and mGlu5) are coupled to polyphosphoinositide hydrolysis and are involved in activity-dependent forms of synaptic plasticity, both during development and in the adult life. Group I mGlu receptors can also regulate proliferation, differentiation, and survival of neural stem/progenitor cells, which further support their role in brain development. An exaggerated response to activation of mGlu5 receptors may underlie synaptic dysfunction in Fragile X syndrome, the most common inherited form of mental retardation. In addition, group I mGlu receptors are overexpressed in dysplastic neurons of focal cortical dysplasia and hemimegaloencephaly, which are disorders of cortical development associated with chronic epilepsy. Drugs that block the activity of group I mGlu receptors (in particular, mGlu5 receptors) are potentially helpful for the treatment of Fragile X syndrome and perhaps other neurodevelopmental disorders.
AB - Group I metabotropic glutamate receptors (mGlu1 and mGlu5) are coupled to polyphosphoinositide hydrolysis and are involved in activity-dependent forms of synaptic plasticity, both during development and in the adult life. Group I mGlu receptors can also regulate proliferation, differentiation, and survival of neural stem/progenitor cells, which further support their role in brain development. An exaggerated response to activation of mGlu5 receptors may underlie synaptic dysfunction in Fragile X syndrome, the most common inherited form of mental retardation. In addition, group I mGlu receptors are overexpressed in dysplastic neurons of focal cortical dysplasia and hemimegaloencephaly, which are disorders of cortical development associated with chronic epilepsy. Drugs that block the activity of group I mGlu receptors (in particular, mGlu5 receptors) are potentially helpful for the treatment of Fragile X syndrome and perhaps other neurodevelopmental disorders.
KW - Epilepsy
KW - Fragile X syndrome
KW - FRAX
KW - Malformation of cortical development
KW - Metabotropic glutamate receptors
KW - mGluRs
KW - Neural development
KW - Plasticity
UR - http://www.scopus.com/inward/record.url?scp=36248998214&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=36248998214&partnerID=8YFLogxK
U2 - 10.1007/s12035-007-0022-1
DO - 10.1007/s12035-007-0022-1
M3 - Article
C2 - 17917118
AN - SCOPUS:36248998214
VL - 35
SP - 298
EP - 307
JO - Molecular Neurobiology
JF - Molecular Neurobiology
SN - 0893-7648
IS - 3
ER -