Abstract
Group I metabotropic glutamate receptors (mGlu1 and mGlu5) are coupled to polyphosphoinositide hydrolysis and are involved in activity-dependent forms of synaptic plasticity, both during development and in the adult life. Group I mGlu receptors can also regulate proliferation, differentiation, and survival of neural stem/progenitor cells, which further support their role in brain development. An exaggerated response to activation of mGlu5 receptors may underlie synaptic dysfunction in Fragile X syndrome, the most common inherited form of mental retardation. In addition, group I mGlu receptors are overexpressed in dysplastic neurons of focal cortical dysplasia and hemimegaloencephaly, which are disorders of cortical development associated with chronic epilepsy. Drugs that block the activity of group I mGlu receptors (in particular, mGlu5 receptors) are potentially helpful for the treatment of Fragile X syndrome and perhaps other neurodevelopmental disorders.
| Original language | English |
|---|---|
| Pages (from-to) | 298-307 |
| Number of pages | 10 |
| Journal | Molecular Neurobiology |
| Volume | 35 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Jun 2007 |
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Keywords
- Epilepsy
- Fragile X syndrome
- FRAX
- Malformation of cortical development
- Metabotropic glutamate receptors
- mGluRs
- Neural development
- Plasticity
ASJC Scopus subject areas
- Neuroscience(all)
- Physiology
Cite this
Group I metabotropic glutamate receptors : A role in neurodevelopmental disorders? / Catania, Maria Vincenza; D'Antoni, Simona; Bonaccorso, Carmela Maria; Aronica, Eleonora; Bear, Mark F.; Nicoletti, Ferdinando.
In: Molecular Neurobiology, Vol. 35, No. 3, 06.2007, p. 298-307.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Group I metabotropic glutamate receptors
T2 - A role in neurodevelopmental disorders?
AU - Catania, Maria Vincenza
AU - D'Antoni, Simona
AU - Bonaccorso, Carmela Maria
AU - Aronica, Eleonora
AU - Bear, Mark F.
AU - Nicoletti, Ferdinando
PY - 2007/6
Y1 - 2007/6
N2 - Group I metabotropic glutamate receptors (mGlu1 and mGlu5) are coupled to polyphosphoinositide hydrolysis and are involved in activity-dependent forms of synaptic plasticity, both during development and in the adult life. Group I mGlu receptors can also regulate proliferation, differentiation, and survival of neural stem/progenitor cells, which further support their role in brain development. An exaggerated response to activation of mGlu5 receptors may underlie synaptic dysfunction in Fragile X syndrome, the most common inherited form of mental retardation. In addition, group I mGlu receptors are overexpressed in dysplastic neurons of focal cortical dysplasia and hemimegaloencephaly, which are disorders of cortical development associated with chronic epilepsy. Drugs that block the activity of group I mGlu receptors (in particular, mGlu5 receptors) are potentially helpful for the treatment of Fragile X syndrome and perhaps other neurodevelopmental disorders.
AB - Group I metabotropic glutamate receptors (mGlu1 and mGlu5) are coupled to polyphosphoinositide hydrolysis and are involved in activity-dependent forms of synaptic plasticity, both during development and in the adult life. Group I mGlu receptors can also regulate proliferation, differentiation, and survival of neural stem/progenitor cells, which further support their role in brain development. An exaggerated response to activation of mGlu5 receptors may underlie synaptic dysfunction in Fragile X syndrome, the most common inherited form of mental retardation. In addition, group I mGlu receptors are overexpressed in dysplastic neurons of focal cortical dysplasia and hemimegaloencephaly, which are disorders of cortical development associated with chronic epilepsy. Drugs that block the activity of group I mGlu receptors (in particular, mGlu5 receptors) are potentially helpful for the treatment of Fragile X syndrome and perhaps other neurodevelopmental disorders.
KW - Epilepsy
KW - Fragile X syndrome
KW - FRAX
KW - Malformation of cortical development
KW - Metabotropic glutamate receptors
KW - mGluRs
KW - Neural development
KW - Plasticity
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UR - http://www.scopus.com/inward/citedby.url?scp=36248998214&partnerID=8YFLogxK
U2 - 10.1007/s12035-007-0022-1
DO - 10.1007/s12035-007-0022-1
M3 - Article
C2 - 17917118
AN - SCOPUS:36248998214
VL - 35
SP - 298
EP - 307
JO - Molecular Neurobiology
JF - Molecular Neurobiology
SN - 0893-7648
IS - 3
ER -