Grouping for behavioral and psychological symptoms in dementia: Clinical and biological aspects. Consensus paper of the European Alzheimer disease consortium

Philippe H. Robert, Frans R J Verhey, E. Jane Byrne, Catherine Hurt, Peter Paul De Deyn, Flavio Nobili, Roberta Riello, Guido Rodriguez, Giovanni B. Frisoni, Magda Tsolaki, Nora Kyriazopoulou, Roger Bullock, Alistair Burns, Bruno Vellas

Research output: Contribution to journalArticlepeer-review

Abstract

Behavioral and psychological symptoms of dementia (BPSD), constitute a major clinical component of Alzheimer's disease (AD). There is a growing interest in BPSD as they are responsible for a large share of the suffering of patients and caregivers, and they strongly determine the patient's lifestyle and management. Better detection and understanding of these symptoms is essential to provide appropriate management. This article is a consensus produced by the behavioral group of the European Alzheimer's Disease Consortium (EADC). The aim of this article is to present clinical description and biological correlates of the major behavioral and psychological symptomatology in AD. BPSD is not a unitary concept. Instead, it should be divided into several symptoms or more likely: groups of symptoms, each possibly reflecting a different prevalence, course over time, biological correlate and psychosocial determinants. There is some clinical evidence for clusters within groups of BPSD. Biological studies indicate that patients with AD and BPSD are associated with variations in the pathological features (atrophy, brain perfusion/metabolism, histopathology) when compared to people with AD without BPSD. An individually tailored approach taking all these aspects into account is warranted as it may offer more, and better, pharmacological and non-pharmacological treatment opportunities.

Original languageEnglish
Pages (from-to)490-496
Number of pages7
JournalEuropean Psychiatry
Volume20
Issue number7
DOIs
Publication statusPublished - Nov 2005

Keywords

  • Alzheimer's disease
  • Behavioral disturbances
  • Dementia

ASJC Scopus subject areas

  • Psychiatry and Mental health

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