Growth and bone metabolism of newborns with intrauterine growth retardation

We studied 38 newborns (16 females) born at term, with birth weight 50th centile of the reference). The urinary excretion of collagen cross-links at day 14 was higher in infants with p.i above the 10th centile of the reference and in children who later showed catch-up growth (1070±494 nmol Pyd/mmol cr, 264±207 nmol Dpd/mmol cr; n=28) than in infants with pi. below the 10th centile who did not overcome their growth problem (672±360 nmol Pyd/mmol cr, 181 ±90 nmol Dpd/mmol cr: n5) However, the difference was of borderline significance (0.10).