Growth and metastasis of the Lewis lung carcinoma in mice defibrinated with batroxobin

M. B. Donati, L. Mussoni, A. Poggi, G. De Gaetano, S. Garattini

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Abstract

Lewis lung carcinoma (3LL) cells were implanted intramuscularly into C57B16J mice, rendered hypofibrinogenemic by daily intraperitoneal treatment with batroxobin (17.5 NIH u/kg body wt, twice per day). When this treatment was continued till spontaneous death of the animals, an increase in both metastasis number and weight was observed, but the primary tumor growth was unchanged. In contrast, both metastasis number and weight tended to decrease when defibrination was started from day 11 after tumor implantation, independently from surgical removal of the primary tumor. These data suggest that fibrinogen and/or its derivatives could play a different role in the various stages of the growth and dissemination of the same experimental tumor.

Original languageEnglish
Pages (from-to)343-347
Number of pages5
JournalEuropean Journal of Cancer (1965)
Volume14
Issue number4
DOIs
Publication statusPublished - 1978

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Batroxobin
Lewis Lung Carcinoma
Neoplasm Metastasis
Growth
Neoplasms
Weights and Measures
Fibrinogen

ASJC Scopus subject areas

  • Oncology

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Growth and metastasis of the Lewis lung carcinoma in mice defibrinated with batroxobin. / Donati, M. B.; Mussoni, L.; Poggi, A.; De Gaetano, G.; Garattini, S.

In: European Journal of Cancer (1965), Vol. 14, No. 4, 1978, p. 343-347.

Research output: Contribution to journalArticle

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AU - Garattini, S.

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AB - Lewis lung carcinoma (3LL) cells were implanted intramuscularly into C57B16J mice, rendered hypofibrinogenemic by daily intraperitoneal treatment with batroxobin (17.5 NIH u/kg body wt, twice per day). When this treatment was continued till spontaneous death of the animals, an increase in both metastasis number and weight was observed, but the primary tumor growth was unchanged. In contrast, both metastasis number and weight tended to decrease when defibrination was started from day 11 after tumor implantation, independently from surgical removal of the primary tumor. These data suggest that fibrinogen and/or its derivatives could play a different role in the various stages of the growth and dissemination of the same experimental tumor.

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