Lewis lung carcinoma (3LL) cells were implanted intramuscularly into C57B16J mice, rendered hypofibrinogenemic by daily intraperitoneal treatment with batroxobin (17.5 NIH u/kg body wt, twice per day). When this treatment was continued till spontaneous death of the animals, an increase in both metastasis number and weight was observed, but the primary tumor growth was unchanged. In contrast, both metastasis number and weight tended to decrease when defibrination was started from day 11 after tumor implantation, independently from surgical removal of the primary tumor. These data suggest that fibrinogen and/or its derivatives could play a different role in the various stages of the growth and dissemination of the same experimental tumor.
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