Growth and pubertal disorders in neurofibromatosis type 1

R. Virdis, M. E. Street, M. A. Bandello, C. Tripodi, A. Donadio, A. R. Villani, L. Cagozzi, L. Garaveli, S. Bernasconi

Research output: Contribution to journalArticle

Abstract

The first textbook of Pediatric Endocrinology in the early 1950s reported an association of neurofibromatosis type 1 (NF1) and precocious puberty (PP) and/or short stature. Recent studies have indicated that children with NF1 grow normally until puberty; thereafter height velocity and relative height (SDS or percentiles) decreases with respect to healthy peers, reaching a mean adult height close to the 25th percentile for the general population. Moreover, the percentage of patients with true short stature (2 SD): 16% vs 6.8% (mothers) vs 3.4% (controls) (p

Original languageEnglish
Pages (from-to)289-292
Number of pages4
JournalJournal of Pediatric Endocrinology and Metabolism
Volume16
Issue numberSUPPL. 2
Publication statusPublished - 2003

Fingerprint

Growth Disorders
Neurofibromatosis 1
Precocious Puberty
Textbooks
Endocrinology
Puberty
Mothers
Pediatrics
Population

Keywords

  • Delayed puberty
  • GnRH agonist therapy
  • Growth
  • Neurofibromatosis type 1
  • Optic gliomas
  • Optic pathway tumors
  • Precocious puberty

ASJC Scopus subject areas

  • Endocrinology
  • Pediatrics, Perinatology, and Child Health

Cite this

Virdis, R., Street, M. E., Bandello, M. A., Tripodi, C., Donadio, A., Villani, A. R., ... Bernasconi, S. (2003). Growth and pubertal disorders in neurofibromatosis type 1. Journal of Pediatric Endocrinology and Metabolism, 16(SUPPL. 2), 289-292.

Growth and pubertal disorders in neurofibromatosis type 1. / Virdis, R.; Street, M. E.; Bandello, M. A.; Tripodi, C.; Donadio, A.; Villani, A. R.; Cagozzi, L.; Garaveli, L.; Bernasconi, S.

In: Journal of Pediatric Endocrinology and Metabolism, Vol. 16, No. SUPPL. 2, 2003, p. 289-292.

Research output: Contribution to journalArticle

Virdis, R, Street, ME, Bandello, MA, Tripodi, C, Donadio, A, Villani, AR, Cagozzi, L, Garaveli, L & Bernasconi, S 2003, 'Growth and pubertal disorders in neurofibromatosis type 1', Journal of Pediatric Endocrinology and Metabolism, vol. 16, no. SUPPL. 2, pp. 289-292.
Virdis R, Street ME, Bandello MA, Tripodi C, Donadio A, Villani AR et al. Growth and pubertal disorders in neurofibromatosis type 1. Journal of Pediatric Endocrinology and Metabolism. 2003;16(SUPPL. 2):289-292.
Virdis, R. ; Street, M. E. ; Bandello, M. A. ; Tripodi, C. ; Donadio, A. ; Villani, A. R. ; Cagozzi, L. ; Garaveli, L. ; Bernasconi, S. / Growth and pubertal disorders in neurofibromatosis type 1. In: Journal of Pediatric Endocrinology and Metabolism. 2003 ; Vol. 16, No. SUPPL. 2. pp. 289-292.
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