Growth factors and human pituitary adenomas

Anna Spada, Andrea Lania

Research output: Contribution to journalArticle

Abstract

In recent years the demonstration that human pituitary adenomas are monoclonal provides further evidence of genomic mutations occurring in the progenitor cell that subsequently undergoes clonal expansion. Up to now the only mutations identified in a significant proportion of pituitary tumors, and particular in GH-secreting adenomas, occur in the Gsα gene and cause constitutive activation of the cAMP pathway. Subsequent studies revealed that these mutations are associated with several feedback mechanisms that, at least in part, counteract the oncogenic potential of mutant Gsα. As far as the promoting agents are concerned, several lines of evidence indicate that in pituitary tumors growth factors or their receptors may be overexpressed at variable levels. The contribution of these defects in human pituitary tumorigenesis remains to be established.

Original languageEnglish
Pages (from-to)63-68
Number of pages6
JournalMolecular and Cellular Endocrinology
Volume197
Issue number1-2
DOIs
Publication statusPublished - Nov 29 2002

Keywords

  • GPCR
  • Growth factors
  • Pituitary adenomas

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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