Abstract

Data from pre-clinical and clinical studies provide evidence that colony-stimulating factors (CSFs) and other growth factors (GFs) can improve stroke outcome by reducing stroke damage through their anti-apoptotic and anti-inflammatory effects, and by promoting angiogenesis and neurogenesis. This review provides a critical and up-to-date literature review on CSF use in stroke. We searched for experimental and clinical studies on haemopoietic GFs such as granulocyte CSF, erythropoietin, granulocyte-macrophage colony-stimulating factor, stem cell factor (SCF), vascular endothelial GF, stromal cell-derived factor-1α and SCF in ischemic stroke. We also considered studies on insulin-like growth factor-1 and neurotrophins. Despite promising results from animal models, the lack of data in human beings hampers efficacy assessments of GFs on stroke outcome. We provide a comprehensive and critical view of the present knowledge about GFs and stroke, and an overview of ongoing and future prospects.

Original languageEnglish
Pages (from-to)1645-1687
Number of pages43
JournalJournal of Cellular and Molecular Medicine
Volume15
Issue number8
DOIs
Publication statusPublished - Aug 2011

Fingerprint

Intercellular Signaling Peptides and Proteins
Stroke
Colony-Stimulating Factors
Stem Cell Factor
Vascular Endothelial Growth Factors
Chemokine CXCL12
Neurogenesis
Nerve Growth Factors
Somatomedins
Granulocyte Colony-Stimulating Factor
Granulocyte-Macrophage Colony-Stimulating Factor
Erythropoietin
Anti-Inflammatory Agents
Animal Models
Clinical Studies

Keywords

  • EPO
  • G-CSF
  • GM-CSF
  • Growth factors
  • IGF-1
  • SCF
  • SDF-1α
  • Stroke
  • VEGF

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Medicine

Cite this

Growth factors in ischemic stroke. / Lanfranconi, S.; Locatelli, F.; Corti, S.; Candelise, L.; Comi, G. P.; Baron, P. L.; Strazzer, S.; Bresolin, N.; Bersano, A.

In: Journal of Cellular and Molecular Medicine, Vol. 15, No. 8, 08.2011, p. 1645-1687.

Research output: Contribution to journalArticle

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