Abstract
Data from pre-clinical and clinical studies provide evidence that colony-stimulating factors (CSFs) and other growth factors (GFs) can improve stroke outcome by reducing stroke damage through their anti-apoptotic and anti-inflammatory effects, and by promoting angiogenesis and neurogenesis. This review provides a critical and up-to-date literature review on CSF use in stroke. We searched for experimental and clinical studies on haemopoietic GFs such as granulocyte CSF, erythropoietin, granulocyte-macrophage colony-stimulating factor, stem cell factor (SCF), vascular endothelial GF, stromal cell-derived factor-1α and SCF in ischemic stroke. We also considered studies on insulin-like growth factor-1 and neurotrophins. Despite promising results from animal models, the lack of data in human beings hampers efficacy assessments of GFs on stroke outcome. We provide a comprehensive and critical view of the present knowledge about GFs and stroke, and an overview of ongoing and future prospects.
| Original language | English |
|---|---|
| Pages (from-to) | 1645-1687 |
| Number of pages | 43 |
| Journal | Journal of Cellular and Molecular Medicine |
| Volume | 15 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Aug 2011 |
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Keywords
- EPO
- G-CSF
- GM-CSF
- Growth factors
- IGF-1
- SCF
- SDF-1α
- Stroke
- VEGF
ASJC Scopus subject areas
- Cell Biology
- Molecular Medicine
Cite this
Growth factors in ischemic stroke. / Lanfranconi, S.; Locatelli, F.; Corti, S.; Candelise, L.; Comi, G. P.; Baron, P. L.; Strazzer, S.; Bresolin, N.; Bersano, A.
In: Journal of Cellular and Molecular Medicine, Vol. 15, No. 8, 08.2011, p. 1645-1687.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Growth factors in ischemic stroke
AU - Lanfranconi, S.
AU - Locatelli, F.
AU - Corti, S.
AU - Candelise, L.
AU - Comi, G. P.
AU - Baron, P. L.
AU - Strazzer, S.
AU - Bresolin, N.
AU - Bersano, A.
PY - 2011/8
Y1 - 2011/8
N2 - Data from pre-clinical and clinical studies provide evidence that colony-stimulating factors (CSFs) and other growth factors (GFs) can improve stroke outcome by reducing stroke damage through their anti-apoptotic and anti-inflammatory effects, and by promoting angiogenesis and neurogenesis. This review provides a critical and up-to-date literature review on CSF use in stroke. We searched for experimental and clinical studies on haemopoietic GFs such as granulocyte CSF, erythropoietin, granulocyte-macrophage colony-stimulating factor, stem cell factor (SCF), vascular endothelial GF, stromal cell-derived factor-1α and SCF in ischemic stroke. We also considered studies on insulin-like growth factor-1 and neurotrophins. Despite promising results from animal models, the lack of data in human beings hampers efficacy assessments of GFs on stroke outcome. We provide a comprehensive and critical view of the present knowledge about GFs and stroke, and an overview of ongoing and future prospects.
AB - Data from pre-clinical and clinical studies provide evidence that colony-stimulating factors (CSFs) and other growth factors (GFs) can improve stroke outcome by reducing stroke damage through their anti-apoptotic and anti-inflammatory effects, and by promoting angiogenesis and neurogenesis. This review provides a critical and up-to-date literature review on CSF use in stroke. We searched for experimental and clinical studies on haemopoietic GFs such as granulocyte CSF, erythropoietin, granulocyte-macrophage colony-stimulating factor, stem cell factor (SCF), vascular endothelial GF, stromal cell-derived factor-1α and SCF in ischemic stroke. We also considered studies on insulin-like growth factor-1 and neurotrophins. Despite promising results from animal models, the lack of data in human beings hampers efficacy assessments of GFs on stroke outcome. We provide a comprehensive and critical view of the present knowledge about GFs and stroke, and an overview of ongoing and future prospects.
KW - EPO
KW - G-CSF
KW - GM-CSF
KW - Growth factors
KW - IGF-1
KW - SCF
KW - SDF-1α
KW - Stroke
KW - VEGF
UR - http://www.scopus.com/inward/record.url?scp=79960329186&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79960329186&partnerID=8YFLogxK
U2 - 10.1111/j.1582-4934.2009.00987.x
DO - 10.1111/j.1582-4934.2009.00987.x
M3 - Article
C2 - 20015202
AN - SCOPUS:79960329186
VL - 15
SP - 1645
EP - 1687
JO - Journal of Cellular and Molecular Medicine
JF - Journal of Cellular and Molecular Medicine
SN - 1582-1838
IS - 8
ER -