Growth factors in preeclampsia: A vascular disease model: A failed vasodilation and angiogenic challenge from pregnancy onwards?

E. Conti, L. Zezza, E. Ralli, D. Caserta, M. B. Musumeci, M. Moscarini, C. Autore, M. Volpe

Research output: Contribution to journalArticle

Abstract

Preeclampsia is the major cause of maternofetal and neonatal morbi-mortality including intrauterine growth retardation, miscarriages and stillbirths. Inadequate vascular dilation and angiogenesis represent the crucial underlying defect of gravidic hypertension, denoting a failed response to the vasodilatory and pro-angiogenic challenge imposed by pregnancy, especially if multifetal. A similar pathogenesis appears involved in gestational diabetes. In this review we aimed to provide a hint on understanding the deeply involved angiogenic disorders which eventually culminate in utero-placental failure. The key players in these complex processes may be found in an intricate network of growth factors (GFs) and GF inhibitors, controlled by several vascular risk factors modulated by environment and genes, which eventually impact on early and late cardiovascular outcomes of mother and fetus.

Original languageEnglish
Pages (from-to)411-425
Number of pages15
JournalCytokine and Growth Factor Reviews
Volume24
Issue number5
DOIs
Publication statusPublished - Oct 2013

Keywords

  • Angiogenesis
  • Growth factors and cytokines
  • Insulin-like growth factor-1
  • Preeclampsia/pregnancy
  • Vasodilation.

ASJC Scopus subject areas

  • Immunology
  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Biochemistry, Genetics and Molecular Biology(all)

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