We report our experience in 8 patients affected with chronic cutaneous ulcerations of the lower limbs who have been treated with local periulcerative injections of granulocyte-macrophage colony stimulating factor (GM-CSF, Mielogen fl 150 μg, Schering-Plough). The clinical beneficial effect obtained stimulated us to investigate the mechanism of action of GM-CSF on wound healing. Thus, we report the preliminary results of the "in situ" hybridazion analysis expression on local expression of vascular epidermal growth factor after treatment with GM-CSF.
|Number of pages||4|
|Journal||Impegno Ospedaliero, Sezione Scientifica|
|Publication status||Published - 2002|
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