Thyrotropin-releasing hormone (TRH) was administered iv to 10 patients with severe liver disease and 10 control subjects. Injection of 400 μg TRH as a bolus induced in 7 out of 10 patients a clear-cut GH rise (≥10 ng/ml) occurring 15-120 min after the injection, and no effect on GH levels in controls. Mean baseline GH levels were higher in patients than in controls. An exaggerated and sustained PRL rise was present after TRH in the subjects with liver disease, whose mean baseline plasma PRL levels were within normal range.
|Number of pages||7|
|Journal||Journal of Clinical Endocrinology and Metabolism|
|Publication status||Published - 1977|
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism