Abstract
Nineteen women with polycystic ovarian disease (PCO; 9 obese) and 15 normal ovulatory women (7 obese) were studied at their follicular phase. All patients had an oral glucose tolerance test (OGTT) before and after treatment with gonadotropin-releasing hormone (GnRH) agonist (Buserelin 400 μg/die s.c. for 8 weeks) to investigate the relationship between ovarian steroidogenesis and insulin and growth hormone (GH) and insulin-like growth factor (SmC) secretion. Luteinizing hormone, follicle-stimulating, estradiol, androstenedione, testosterone, dehydroepiandrosterone sulfate, cortisol, insulin, GH and SmC were measured basally at the time of OGTT. PCO patients showed higher androgen basal levels than control patients. All subjects showed a normal glycemic response to OGTT. The mean fasting level and area under the curve of plasma insulin were also significantly greater in PCO than in control patients (p
Original language | English |
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Pages (from-to) | 149-153 |
Number of pages | 5 |
Journal | Gynecologic and Obstetric Investigation |
Volume | 29 |
Issue number | 2 |
Publication status | Published - 1990 |
Keywords
- androgens
- Growth hormone
- insulin
- polycystic ovarian disease
- somatomedin C
ASJC Scopus subject areas
- Obstetrics and Gynaecology