Growth hormone and somatomedin-C secretion in patients with polycystic ovarian disease. Their relationships with hyperinsulinism and hyperandrogenism

A. Lanzone; A. M. Fulghesu; S. Pappalardo; C. Proto; M. Le Donne; C. L. Andreani; R. Muscatello; A. Caruso; S. Mancuso

Growth hormone and somatomedin-C secretion in patients with polycystic ovarian disease. Their relationships with hyperinsulinism and hyperandrogenism

A. Lanzone, A. M. Fulghesu, S. Pappalardo, C. Proto, M. Le Donne, C. L. Andreani, R. Muscatello, A. Caruso, S. Mancuso

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Research output: Contribution to journal › Article › peer-review

Abstract

Nineteen women with polycystic ovarian disease (PCO; 9 obese) and 15 normal ovulatory women (7 obese) were studied at their follicular phase. All patients had an oral glucose tolerance test (OGTT) before and after treatment with gonadotropin-releasing hormone (GnRH) agonist (Buserelin 400 μg/die s.c. for 8 weeks) to investigate the relationship between ovarian steroidogenesis and insulin and growth hormone (GH) and insulin-like growth factor (SmC) secretion. Luteinizing hormone, follicle-stimulating, estradiol, androstenedione, testosterone, dehydroepiandrosterone sulfate, cortisol, insulin, GH and SmC were measured basally at the time of OGTT. PCO patients showed higher androgen basal levels than control patients. All subjects showed a normal glycemic response to OGTT. The mean fasting level and area under the curve of plasma insulin were also significantly greater in PCO than in control patients (p

Original language	English
Pages (from-to)	149-153
Number of pages	5
Journal	Gynecologic and Obstetric Investigation
Volume	29
Issue number	2
Publication status	Published - 1990

Keywords

androgens
Growth hormone
insulin
polycystic ovarian disease
somatomedin C

ASJC Scopus subject areas

Obstetrics and Gynaecology

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Growth hormone and somatomedin-C secretion in patients with polycystic ovarian disease. Their relationships with hyperinsulinism and hyperandrogenism. / Lanzone, A.; Fulghesu, A. M.; Pappalardo, S.; Proto, C.; Le Donne, M.; Andreani, C. L.; Muscatello, R.; Caruso, A.; Mancuso, S.

In: Gynecologic and Obstetric Investigation, Vol. 29, No. 2, 1990, p. 149-153.

Research output: Contribution to journal › Article › peer-review

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AU - Proto, C.

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AU - Andreani, C. L.

AU - Muscatello, R.

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