Growth hormone and somatomedin-C secretion in patients with polycystic ovarian disease. Their relationships with hyperinsulinism and hyperandrogenism

A. Lanzone, A. M. Fulghesu, S. Pappalardo, C. Proto, M. Le Donne, C. L. Andreani, R. Muscatello, A. Caruso, S. Mancuso

Research output: Contribution to journalArticlepeer-review

Abstract

Nineteen women with polycystic ovarian disease (PCO; 9 obese) and 15 normal ovulatory women (7 obese) were studied at their follicular phase. All patients had an oral glucose tolerance test (OGTT) before and after treatment with gonadotropin-releasing hormone (GnRH) agonist (Buserelin 400 μg/die s.c. for 8 weeks) to investigate the relationship between ovarian steroidogenesis and insulin and growth hormone (GH) and insulin-like growth factor (SmC) secretion. Luteinizing hormone, follicle-stimulating, estradiol, androstenedione, testosterone, dehydroepiandrosterone sulfate, cortisol, insulin, GH and SmC were measured basally at the time of OGTT. PCO patients showed higher androgen basal levels than control patients. All subjects showed a normal glycemic response to OGTT. The mean fasting level and area under the curve of plasma insulin were also significantly greater in PCO than in control patients (p

Original languageEnglish
Pages (from-to)149-153
Number of pages5
JournalGynecologic and Obstetric Investigation
Volume29
Issue number2
Publication statusPublished - 1990

Keywords

  • androgens
  • Growth hormone
  • insulin
  • polycystic ovarian disease
  • somatomedin C

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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