Growth Hormone as Biomarker in Heart Failure

Alberto M. Marra; Emanuele Bobbio; Roberta D'Assante; Andrea Salzano; Michele Arcopinto; Eduardo Bossone; Antonio Cittadini

doi:10.1016/j.hfc.2017.08.008

Growth Hormone as Biomarker in Heart Failure

Alberto M. Marra, Emanuele Bobbio, Roberta D'Assante, Andrea Salzano, Michele Arcopinto, Eduardo Bossone, Antonio Cittadini

Research output: Contribution to journal › Review article › peer-review

Abstract

The impairment of growth hormone (GH)/insulin growth factor-1(IGF-1) plays a crucial role in chronic heart failure (CHF). Several studies have shown that patients affected by this condition display a more aggressive disease, with impaired functional capacity and poor outcomes. Interestingly, GH replacement therapy represents a possible future therapeutic option in CHF. In this review, the authors focus on the assessment of the main abnormalities in GH/IGF-1 axis in CHF, the underlying molecular background, and their impact on disease progression and outcomes.

Original language	English
Pages (from-to)	65-74
Number of pages	10
Journal	Heart Failure Clinics
Volume	14
Issue number	1
DOIs	https://doi.org/10.1016/j.hfc.2017.08.008
Publication status	E-pub ahead of print - Nov 17 2017

Keywords

Anabolic deficiency
Biomarker
Chronic heart failure
Growth hormone
IGF-1
Outcomes

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.hfc.2017.08.008

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title = "Growth Hormone as Biomarker in Heart Failure",

abstract = "The impairment of growth hormone (GH)/insulin growth factor-1(IGF-1) plays a crucial role in chronic heart failure (CHF). Several studies have shown that patients affected by this condition display a more aggressive disease, with impaired functional capacity and poor outcomes. Interestingly, GH replacement therapy represents a possible future therapeutic option in CHF. In this review, the authors focus on the assessment of the main abnormalities in GH/IGF-1 axis in CHF, the underlying molecular background, and their impact on disease progression and outcomes.",

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AU - Marra, Alberto M.

AU - Bobbio, Emanuele

AU - D'Assante, Roberta

AU - Salzano, Andrea

AU - Arcopinto, Michele

AU - Bossone, Eduardo

AU - Cittadini, Antonio

PY - 2017/11/17

Y1 - 2017/11/17

N2 - The impairment of growth hormone (GH)/insulin growth factor-1(IGF-1) plays a crucial role in chronic heart failure (CHF). Several studies have shown that patients affected by this condition display a more aggressive disease, with impaired functional capacity and poor outcomes. Interestingly, GH replacement therapy represents a possible future therapeutic option in CHF. In this review, the authors focus on the assessment of the main abnormalities in GH/IGF-1 axis in CHF, the underlying molecular background, and their impact on disease progression and outcomes.

AB - The impairment of growth hormone (GH)/insulin growth factor-1(IGF-1) plays a crucial role in chronic heart failure (CHF). Several studies have shown that patients affected by this condition display a more aggressive disease, with impaired functional capacity and poor outcomes. Interestingly, GH replacement therapy represents a possible future therapeutic option in CHF. In this review, the authors focus on the assessment of the main abnormalities in GH/IGF-1 axis in CHF, the underlying molecular background, and their impact on disease progression and outcomes.

KW - Anabolic deficiency

KW - Biomarker

KW - Chronic heart failure

KW - Growth hormone

KW - IGF-1

KW - Outcomes

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Growth Hormone as Biomarker in Heart Failure

Abstract

Keywords

ASJC Scopus subject areas

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