Growth hormone bioactivity and levels of growth hormone, growth hormone- binding protein, insulinlike growth factor I, and insulinlike growth factor- binding proteins in premature and full-term newborns during the first month of life

Giorgio Radetti, Mauro Bozzola, Claudio Paganini, Roberta Valentini, Lino Gentili, Katia Tettoni, Luciano Tatò

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To assess the pattern of growth hormone bioactivity (GH-BIO) and the levels of GH-binding protein (GH-BP), insulinlike growth factor I (IGF-I), and insulinlike growth factor-binding proteins (IGFBPs) in the first month of life in premature and full-term (FT) newborns. Patients and Methods: Serum samples were collected from 9 premature newborns who were small for gestational age, 18 premature newborns who were of appropriate size for gestational age, and 20 FT newborns on the 4th and 30th days of life to evaluate the GH-BIO using the Nb2 cell bioassay, the GH levels using a radioimmunoassay (GH-RIA), and the levels of GH-BP, IGF-I, and IGFBPs. Results: On day 4, the GH-RIA and GH-BIO values were increased in all newborns (P

Original languageEnglish
Pages (from-to)170-175
Number of pages6
JournalArchives of Pediatrics and Adolescent Medicine
Volume151
Issue number2
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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