Growth hormone bioactivity, insulin-like growth factors (IGFs), and IGF binding proteins in obese children

G. Radetti, M. Bozzola, B. Pasquino, C. Paganini, A. Aglialoro, C. Livieri, A. Barreca

Research output: Contribution to journalArticle

Abstract

In obese children, both spontaneous and stimulated growth hormone (GH) secretion are impaired but a normal or increased height velocity is usually observed. This study was undertaken to explain the discrepancy between impaired GH secretion and normal height velocity. We evaluated the GH bioactivity (GH-BIO), GH serum level by immunofluorimetric assay (GH-IFMA), insulin-like growth factor-I (IGF-I), IGF-II, and IGF binding protein-1 (IGFBP-1), IGFBP-2, and IGFBP-3 in 21 prepubertal obese children (13 boys and eight girls) aged 5.7 to 9.4 years affected by simple obesity and in 32 (22 boys and 10 girls) age- and sex-matched normal-weight controls. The results were as follows (obese versus [v] controls): GH-IFMA, 4.84 ± 3.54 v 23.7 ± 2.04 μg/L (P<.001); GH-BIO, 0.60 ± 0.45 v 1.84 ± 0.15 U/mL (P <.001); IGF-I, 173.8 ± 57.2 v 188.6 ± 132.6 ng/mL (nonsignificant); IGF-II, 596.1 ± 139.7 v 439.3 ± 127.4 ng/mL (P <.001); IGFBP-1, 23.25 ± 14.25 v 107 ± 165.7 ng/mL (P <.05); IGFBP-2, 44.37 ± 62.18 v 385.93 ± 227.81 ng/mL (P <.001); IGFBP-3, 3.31 ± 0.82 v2.6 ± 0.94 μg/mL (P <.05); and IGFs/IGFBPs, 1.32 ± 0.32 v 1.07 ± 0.34 (P <.05). In conclusion, in prepubertal obese children, not only immunoreactive but also bioactive GH concentrations were low. In these subjects, therefore, nutritional factors and insulin may contribute to sustain normal growth also by modulating several components of the IGF-IGFBP system.

Original languageEnglish
Pages (from-to)1490-1493
Number of pages4
JournalMetabolism
Volume47
Issue number12
Publication statusPublished - 1998

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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    Radetti, G., Bozzola, M., Pasquino, B., Paganini, C., Aglialoro, A., Livieri, C., & Barreca, A. (1998). Growth hormone bioactivity, insulin-like growth factors (IGFs), and IGF binding proteins in obese children. Metabolism, 47(12), 1490-1493.