Growth hormone deficiency: Diagnosis and therapy in childrenf

Mauro Bozzola, Cristina Meazza

Research output: Contribution to journalArticlepeer-review


Growth hormone (GH) deficiency (GHD) represents a condition characterized by reduced GH secretion, isolated or associated with other pituitary hormone deficiencies. Diagnosis of GHD in childhood is achieved by secretagogs testing in combination with auxological parameters, such as height and growth velocity and biochemical and radiological findings. Only after excluding other causes of growth failure should a careful assessment of the pituitary-IGF-1 axis be undertaken, using GH-provocative tests and basal serum IGF-I values. As recommended by the GH Research Society, patients with GHD should be treated with recombinant human GH in order to normalize height during childhood and, ultimately, attain a normal adult height.

Original languageEnglish
Pages (from-to)273-284
Number of pages12
JournalExpert Review of Endocrinology and Metabolism
Issue number2
Publication statusPublished - Mar 2010


  • Children
  • Growth hormone
  • Growth hormone deficiency
  • Growth hormone therapy
  • Short stature

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism


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