Growth Hormone Deficiency in Elderly Patients with Hypothalamo-Pituitary Tumors

Annamaria Colao, Gaetana Cerbone, Rosario Pivonello, Michele Klain, Gianluca Aimaretti, Antongiulio Faggiano, Carolina Di Somma, Marco Salvatore, Gaetano Lombardi

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

In 18 patients with hypothalamo-pituitary diseases aged over 60 years and in 18 sex, age- and BMI-matched healthy subjects, the results of plasma IGF-I and IGF-BP3 levels and the GH response to GHRH+arginine test (GHRH+ATT) were correlated to the results of body composition, serum osteocalcin (OC) and urinary cross-linked N-telopeptides of type I collagen (Ntx) and the bone mineral density (BMD). In 10 patients and 10 controls, the GH response to ITT was also evaluated. The GH response to GHRH+ATT and ITT was markedly reduced in patients compared to controls (3.1 ± 0.7 vs. 23.2 ± 2.3 μg/L, P <0.001 and 1.1 ± 0.3 vs. 6.4 ± 0.8 μg/L, P <0.001), so all patients were classified as GHD, though no significant difference was found in plasma IGF-I and IGF-BP3 levels between the two groups. Body composition analysis revealed a significant increase of fat mass (37.4 ± 2.2 vs. 28.0 ± 1.0%, P <0.001), a significant decrease of lean mass (62.6 ± 2.2 vs. 72.0 ± 1.0%, P <0.001) and total body water (45.7 ± 1.5 vs. 52.5 ± 1.1%, P <0.001) in patients compared to controls. Serum OC levels were lower (1.9 ± 0.1 vs. 4.6 ± 0.4 μg/L, P <0.001) in patients than in controls, whereas urinary Ntx levels were similar. BMD values in lumbar spine (0.81 ± 0.02 vs. 0.90 ± 0.02 g/cm2, P <0.01) and femoral neck (0.70 ± 0.02 vs. 0.82 ± 0.02 g/cm2, P <0.001) were significantly lower in patients than in controls. A significant inverse correlation was found between GHD duration and lumbar spine (r = -0.73, P&1t; 0.001) or femoral neck (r = -0.81, P&1t; 0.001) BMD values and a significant direct correlation was found between GH peak after GHRH+ATT and lumbar BMD (r = 0.69, p = 0.001) in GHD patients. In conclusion, GHD in patients over 60 yrs aged with a characteristic history of hypothalamus-pituitary pathology is distinct from the physiological decline in GH secretion associated with aging.

Original languageEnglish
Pages (from-to)59-67
Number of pages9
JournalPituitary
Volume1
Issue number1
Publication statusPublished - 1998

Fingerprint

Pituitary Neoplasms
Growth Hormone
Bone Density
Arginine
Femur Neck
Osteocalcin
Body Composition
Insulin-Like Growth Factor I
Spine
Pituitary Diseases
Body Water
Collagen Type I
Serum
Hypothalamus
Healthy Volunteers
Fats
Pathology

Keywords

  • GH
  • GH deficiency
  • IGF-I binding proteins
  • Pituitary diseases

ASJC Scopus subject areas

  • Endocrinology

Cite this

Colao, A., Cerbone, G., Pivonello, R., Klain, M., Aimaretti, G., Faggiano, A., ... Lombardi, G. (1998). Growth Hormone Deficiency in Elderly Patients with Hypothalamo-Pituitary Tumors. Pituitary, 1(1), 59-67.

Growth Hormone Deficiency in Elderly Patients with Hypothalamo-Pituitary Tumors. / Colao, Annamaria; Cerbone, Gaetana; Pivonello, Rosario; Klain, Michele; Aimaretti, Gianluca; Faggiano, Antongiulio; Di Somma, Carolina; Salvatore, Marco; Lombardi, Gaetano.

In: Pituitary, Vol. 1, No. 1, 1998, p. 59-67.

Research output: Contribution to journalArticle

Colao, A, Cerbone, G, Pivonello, R, Klain, M, Aimaretti, G, Faggiano, A, Di Somma, C, Salvatore, M & Lombardi, G 1998, 'Growth Hormone Deficiency in Elderly Patients with Hypothalamo-Pituitary Tumors', Pituitary, vol. 1, no. 1, pp. 59-67.
Colao A, Cerbone G, Pivonello R, Klain M, Aimaretti G, Faggiano A et al. Growth Hormone Deficiency in Elderly Patients with Hypothalamo-Pituitary Tumors. Pituitary. 1998;1(1):59-67.
Colao, Annamaria ; Cerbone, Gaetana ; Pivonello, Rosario ; Klain, Michele ; Aimaretti, Gianluca ; Faggiano, Antongiulio ; Di Somma, Carolina ; Salvatore, Marco ; Lombardi, Gaetano. / Growth Hormone Deficiency in Elderly Patients with Hypothalamo-Pituitary Tumors. In: Pituitary. 1998 ; Vol. 1, No. 1. pp. 59-67.
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