Growth hormone deficiency in patients with chronic heart failure and beneficial effects of its correction

Antonio Cittadini, Lavinia Saldamarco, Alberto Maria Marra, Michele Arcopinto, Guido Carlomagno, Massimo Imbriaco, Domenico Del Forno, Carlo Vigorito, Bartolomeo Merola, Ugo Oliviero, Serafino Fazio, Luigi Saccà

Research output: Contribution to journalArticlepeer-review

Abstract

Context: A reduced activity of the GH/IGF-I axis in chronic heart failure (CHF) has been described by several independent groups and is associated with poor clinical status and outcome. Objective: The aim of the current study was to investigate the prevalence of GH deficiency in a patient population with CHF and evaluate the cardiovascular effects of GH replacement therapy. Design and Setting: The randomized, single-blind, controlled trial was conducted at the Federico II University. Participants: One hundred fifty-eight patients with CHF, New York Heart Association class II-IV, underwent a GH stimulation test. Sixty-three patients satisfied the criteria for GH deficiency, and 56 of them were enrolled in the trial. Intervention: The treated group (n = 28) received GH at a replacement dose of 0.012 mg/kg every second day (∼2.5 IU). Main Outcomes Measures: Changes in physical performance and various cardiovascular indexes were measured. Results: GH replacement therapy improved quality of life score (from 46 ± 5 to 38 ± 4; P <0.01), increased peak oxygen uptake and exercise duration (from 12.9±.9 to 14.5±1 ml/kg · min and from 520 ± 36 to 586 ± 43 sec, respectively; P <0.01), and flow-mediated vasodilation (from 8.8 ± 1.3 to 12.7±1.2%;P

Original languageEnglish
Pages (from-to)3329-3336
Number of pages8
JournalJournal of Clinical Endocrinology and Metabolism
Volume94
Issue number9
DOIs
Publication statusPublished - Sep 2009

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism

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