Growth hormone hyperresponsiveness to dopaminergic stimulation in Huntington's chorea

E. E. Muller, E. A. Parati, A. E. Panerai, D. Cocchi, T. Caraceni

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The effect of 3 dopamine mimetic drugs, i.e. bromocriptine (Bro), apomorphine (Apo) and L-3,4-dihydroxyphenylalanine (L-dopa), was evaluated on plasma growth hormone (GH) levels in 18 patients with Huntington's chorea (HC). 27 nonobese hospitalized patients were used as controls. Mean baseline GH levels were not altered in patients with HC. Oral administration of Bro (2.5 mg po) or L-dopa (500 mg), or subcutaneous administration of Apo (1.0 mg), resulted in a significantly greater and more prompt (Bro, L-dopa) increase in plasma GH in patients than in controls. These results suggest the presence of an altered dopaminergic regulation of GH secretion in HC.

Original languageEnglish
Pages (from-to)313-319
Number of pages7
JournalNeuroendocrinology
Volume28
Issue number5
Publication statusPublished - 1979

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Huntington Disease
Growth Hormone
Bromocriptine
Levodopa
Apomorphine
Dopamine Agents
Oral Administration

ASJC Scopus subject areas

  • Endocrinology
  • Neuroscience(all)

Cite this

Muller, E. E., Parati, E. A., Panerai, A. E., Cocchi, D., & Caraceni, T. (1979). Growth hormone hyperresponsiveness to dopaminergic stimulation in Huntington's chorea. Neuroendocrinology, 28(5), 313-319.

Growth hormone hyperresponsiveness to dopaminergic stimulation in Huntington's chorea. / Muller, E. E.; Parati, E. A.; Panerai, A. E.; Cocchi, D.; Caraceni, T.

In: Neuroendocrinology, Vol. 28, No. 5, 1979, p. 313-319.

Research output: Contribution to journalArticle

Muller, EE, Parati, EA, Panerai, AE, Cocchi, D & Caraceni, T 1979, 'Growth hormone hyperresponsiveness to dopaminergic stimulation in Huntington's chorea', Neuroendocrinology, vol. 28, no. 5, pp. 313-319.
Muller, E. E. ; Parati, E. A. ; Panerai, A. E. ; Cocchi, D. ; Caraceni, T. / Growth hormone hyperresponsiveness to dopaminergic stimulation in Huntington's chorea. In: Neuroendocrinology. 1979 ; Vol. 28, No. 5. pp. 313-319.
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