Growth hormone hyperresponsiveness to dopaminergic stimulation in Huntington's chorea

E. E. Muller, E. A. Parati, A. E. Panerai, D. Cocchi, T. Caraceni

Research output: Contribution to journalArticle

Abstract

The effect of 3 dopamine mimetic drugs, i.e. bromocriptine (Bro), apomorphine (Apo) and L-3,4-dihydroxyphenylalanine (L-dopa), was evaluated on plasma growth hormone (GH) levels in 18 patients with Huntington's chorea (HC). 27 nonobese hospitalized patients were used as controls. Mean baseline GH levels were not altered in patients with HC. Oral administration of Bro (2.5 mg po) or L-dopa (500 mg), or subcutaneous administration of Apo (1.0 mg), resulted in a significantly greater and more prompt (Bro, L-dopa) increase in plasma GH in patients than in controls. These results suggest the presence of an altered dopaminergic regulation of GH secretion in HC.

Original languageEnglish
Pages (from-to)313-319
Number of pages7
JournalNeuroendocrinology
Volume28
Issue number5
Publication statusPublished - 1979

ASJC Scopus subject areas

  • Endocrinology
  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Growth hormone hyperresponsiveness to dopaminergic stimulation in Huntington's chorea'. Together they form a unique fingerprint.

  • Cite this

    Muller, E. E., Parati, E. A., Panerai, A. E., Cocchi, D., & Caraceni, T. (1979). Growth hormone hyperresponsiveness to dopaminergic stimulation in Huntington's chorea. Neuroendocrinology, 28(5), 313-319.