Growth hormone, prolactin and cortisol nyctohemeral variations during naloxone-induced opiate receptor blockade in man

G. Delitala; M. Giusti; G. Rodriguez; G. Mazzocchi; S. Ferrini; L. Baccelliere; V. Montano; G. Rosadini; G. Giordano

Growth hormone, prolactin and cortisol nyctohemeral variations during naloxone-induced opiate receptor blockade in man

G. Delitala, M. Giusti, G. Rodriguez, G. Mazzocchi, S. Ferrini, L. Baccelliere, V. Montano, G. Rosadini, G. Giordano

A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)

Research output: Contribution to journal › Article › peer-review

Abstract

To evaluate the role of endogenous opioid peptides in prolactin (Prl), growth hormone (GH) and cortisol neuroregulation, 50 mg of the opiate antagonist naloxone was infused over 24 h to 6 normal male volunteers. An additional naloxone dose (5 mg) was given iv as a bolus injection at 20.00 h. Blood specimens were collected hourly by means of a portable constant withdrawal pump. Naloxone failed to alter 24 h secretion of GH and Prl. The sleep-related GH and Prl rise was also unaffected by the opiate blocker. Moreover, naloxone failed to alter the circadian rhythm of cortisol and its 24 h concentration. The results do not suggest a major role of opiate receptors in spontaneous GH, Prl and cortisol secretion in man.

Original language	English
Pages (from-to)	321-326
Number of pages	6
Journal	Acta Endocrinologica
Volume	100
Issue number	3
Publication status	Published - 1982

ASJC Scopus subject areas

Endocrinology

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Growth hormone, prolactin and cortisol nyctohemeral variations during naloxone-induced opiate receptor blockade in man. / Delitala, G.; Giusti, M.; Rodriguez, G.; Mazzocchi, G.; Ferrini, S.; Baccelliere, L.; Montano, V.; Rosadini, G.; Giordano, G.

In: Acta Endocrinologica, Vol. 100, No. 3, 1982, p. 321-326.

Research output: Contribution to journal › Article › peer-review

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abstract = "To evaluate the role of endogenous opioid peptides in prolactin (Prl), growth hormone (GH) and cortisol neuroregulation, 50 mg of the opiate antagonist naloxone was infused over 24 h to 6 normal male volunteers. An additional naloxone dose (5 mg) was given iv as a bolus injection at 20.00 h. Blood specimens were collected hourly by means of a portable constant withdrawal pump. Naloxone failed to alter 24 h secretion of GH and Prl. The sleep-related GH and Prl rise was also unaffected by the opiate blocker. Moreover, naloxone failed to alter the circadian rhythm of cortisol and its 24 h concentration. The results do not suggest a major role of opiate receptors in spontaneous GH, Prl and cortisol secretion in man.",

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AU - Mazzocchi, G.

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AU - Baccelliere, L.

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AU - Rosadini, G.

AU - Giordano, G.

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AB - To evaluate the role of endogenous opioid peptides in prolactin (Prl), growth hormone (GH) and cortisol neuroregulation, 50 mg of the opiate antagonist naloxone was infused over 24 h to 6 normal male volunteers. An additional naloxone dose (5 mg) was given iv as a bolus injection at 20.00 h. Blood specimens were collected hourly by means of a portable constant withdrawal pump. Naloxone failed to alter 24 h secretion of GH and Prl. The sleep-related GH and Prl rise was also unaffected by the opiate blocker. Moreover, naloxone failed to alter the circadian rhythm of cortisol and its 24 h concentration. The results do not suggest a major role of opiate receptors in spontaneous GH, Prl and cortisol secretion in man.

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