Growth hormone, prolactin and cortisol nyctohemeral variations during naloxone-induced opiate receptor blockade in man

G. Delitala, M. Giusti, G. Rodriguez, G. Mazzocchi, S. Ferrini, L. Baccelliere, V. Montano, G. Rosadini, G. Giordano

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

To evaluate the role of endogenous opioid peptides in prolactin (Prl), growth hormone (GH) and cortisol neuroregulation, 50 mg of the opiate antagonist naloxone was infused over 24 h to 6 normal male volunteers. An additional naloxone dose (5 mg) was given iv as a bolus injection at 20.00 h. Blood specimens were collected hourly by means of a portable constant withdrawal pump. Naloxone failed to alter 24 h secretion of GH and Prl. The sleep-related GH and Prl rise was also unaffected by the opiate blocker. Moreover, naloxone failed to alter the circadian rhythm of cortisol and its 24 h concentration. The results do not suggest a major role of opiate receptors in spontaneous GH, Prl and cortisol secretion in man.

Original languageEnglish
Pages (from-to)321-326
Number of pages6
JournalActa Endocrinologica
Volume100
Issue number3
Publication statusPublished - 1982

Fingerprint

Opioid Receptors
Naloxone
Prolactin
Growth Hormone
Hydrocortisone
Opiate Alkaloids
Opioid Peptides
Circadian Rhythm
Healthy Volunteers
Sleep
Injections

ASJC Scopus subject areas

  • Endocrinology

Cite this

Delitala, G., Giusti, M., Rodriguez, G., Mazzocchi, G., Ferrini, S., Baccelliere, L., ... Giordano, G. (1982). Growth hormone, prolactin and cortisol nyctohemeral variations during naloxone-induced opiate receptor blockade in man. Acta Endocrinologica, 100(3), 321-326.

Growth hormone, prolactin and cortisol nyctohemeral variations during naloxone-induced opiate receptor blockade in man. / Delitala, G.; Giusti, M.; Rodriguez, G.; Mazzocchi, G.; Ferrini, S.; Baccelliere, L.; Montano, V.; Rosadini, G.; Giordano, G.

In: Acta Endocrinologica, Vol. 100, No. 3, 1982, p. 321-326.

Research output: Contribution to journalArticle

Delitala, G, Giusti, M, Rodriguez, G, Mazzocchi, G, Ferrini, S, Baccelliere, L, Montano, V, Rosadini, G & Giordano, G 1982, 'Growth hormone, prolactin and cortisol nyctohemeral variations during naloxone-induced opiate receptor blockade in man', Acta Endocrinologica, vol. 100, no. 3, pp. 321-326.
Delitala G, Giusti M, Rodriguez G, Mazzocchi G, Ferrini S, Baccelliere L et al. Growth hormone, prolactin and cortisol nyctohemeral variations during naloxone-induced opiate receptor blockade in man. Acta Endocrinologica. 1982;100(3):321-326.
Delitala, G. ; Giusti, M. ; Rodriguez, G. ; Mazzocchi, G. ; Ferrini, S. ; Baccelliere, L. ; Montano, V. ; Rosadini, G. ; Giordano, G. / Growth hormone, prolactin and cortisol nyctohemeral variations during naloxone-induced opiate receptor blockade in man. In: Acta Endocrinologica. 1982 ; Vol. 100, No. 3. pp. 321-326.
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