Abstract
To evaluate the role of endogenous opioid peptides in prolactin (Prl), growth hormone (GH) and cortisol neuroregulation, 50 mg of the opiate antagonist naloxone was infused over 24 h to 6 normal male volunteers. An additional naloxone dose (5 mg) was given iv as a bolus injection at 20.00 h. Blood specimens were collected hourly by means of a portable constant withdrawal pump. Naloxone failed to alter 24 h secretion of GH and Prl. The sleep-related GH and Prl rise was also unaffected by the opiate blocker. Moreover, naloxone failed to alter the circadian rhythm of cortisol and its 24 h concentration. The results do not suggest a major role of opiate receptors in spontaneous GH, Prl and cortisol secretion in man.
| Original language | English |
|---|---|
| Pages (from-to) | 321-326 |
| Number of pages | 6 |
| Journal | Acta Endocrinologica |
| Volume | 100 |
| Issue number | 3 |
| Publication status | Published - 1982 |
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ASJC Scopus subject areas
- Endocrinology
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Growth hormone, prolactin and cortisol nyctohemeral variations during naloxone-induced opiate receptor blockade in man. / Delitala, G.; Giusti, M.; Rodriguez, G.; Mazzocchi, G.; Ferrini, S.; Baccelliere, L.; Montano, V.; Rosadini, G.; Giordano, G.
In: Acta Endocrinologica, Vol. 100, No. 3, 1982, p. 321-326.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Growth hormone, prolactin and cortisol nyctohemeral variations during naloxone-induced opiate receptor blockade in man
AU - Delitala, G.
AU - Giusti, M.
AU - Rodriguez, G.
AU - Mazzocchi, G.
AU - Ferrini, S.
AU - Baccelliere, L.
AU - Montano, V.
AU - Rosadini, G.
AU - Giordano, G.
PY - 1982
Y1 - 1982
N2 - To evaluate the role of endogenous opioid peptides in prolactin (Prl), growth hormone (GH) and cortisol neuroregulation, 50 mg of the opiate antagonist naloxone was infused over 24 h to 6 normal male volunteers. An additional naloxone dose (5 mg) was given iv as a bolus injection at 20.00 h. Blood specimens were collected hourly by means of a portable constant withdrawal pump. Naloxone failed to alter 24 h secretion of GH and Prl. The sleep-related GH and Prl rise was also unaffected by the opiate blocker. Moreover, naloxone failed to alter the circadian rhythm of cortisol and its 24 h concentration. The results do not suggest a major role of opiate receptors in spontaneous GH, Prl and cortisol secretion in man.
AB - To evaluate the role of endogenous opioid peptides in prolactin (Prl), growth hormone (GH) and cortisol neuroregulation, 50 mg of the opiate antagonist naloxone was infused over 24 h to 6 normal male volunteers. An additional naloxone dose (5 mg) was given iv as a bolus injection at 20.00 h. Blood specimens were collected hourly by means of a portable constant withdrawal pump. Naloxone failed to alter 24 h secretion of GH and Prl. The sleep-related GH and Prl rise was also unaffected by the opiate blocker. Moreover, naloxone failed to alter the circadian rhythm of cortisol and its 24 h concentration. The results do not suggest a major role of opiate receptors in spontaneous GH, Prl and cortisol secretion in man.
UR - http://www.scopus.com/inward/record.url?scp=0019951592&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019951592&partnerID=8YFLogxK
M3 - Article
VL - 100
SP - 321
EP - 326
JO - Acta Endocrinologica
JF - Acta Endocrinologica
SN - 0001-5598
IS - 3
ER -