Growth hormone, prolactin and cortisol nyctohemeral variations during naloxone-induced opiate receptor blockade in man

G. Delitala, M. Giusti, G. Rodriguez, G. Mazzocchi, S. Ferrini, L. Baccelliere, V. Montano, G. Rosadini, G. Giordano

Research output: Contribution to journalArticlepeer-review

Abstract

To evaluate the role of endogenous opioid peptides in prolactin (Prl), growth hormone (GH) and cortisol neuroregulation, 50 mg of the opiate antagonist naloxone was infused over 24 h to 6 normal male volunteers. An additional naloxone dose (5 mg) was given iv as a bolus injection at 20.00 h. Blood specimens were collected hourly by means of a portable constant withdrawal pump. Naloxone failed to alter 24 h secretion of GH and Prl. The sleep-related GH and Prl rise was also unaffected by the opiate blocker. Moreover, naloxone failed to alter the circadian rhythm of cortisol and its 24 h concentration. The results do not suggest a major role of opiate receptors in spontaneous GH, Prl and cortisol secretion in man.

Original languageEnglish
Pages (from-to)321-326
Number of pages6
JournalActa Endocrinologica
Volume100
Issue number3
Publication statusPublished - 1982

ASJC Scopus subject areas

  • Endocrinology

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