Hexarelin (Hex) is a new synthetic GH-releasing peptide (GHRP) which has a potent dose-dependent stimulatory effect on GH secretion in man. The authors studied the GH secretion response in 12 subjects affected by Down syndrome (DS) following 2 μg/kg i.v. administration of Hex. The GH releasing effect was compared with that obtained after clonidine test (CT), insulin tolerance test (ITT), GH releasing hormone test (GHRH), and GHRH plus pyridostigmine (P) test. The results show that Hex is a potent GH stimulator in DS. Its response is similar to GHRH plus P and higher than CT, ITT, and even GHRH. Thus it may be useful for evaluating the secretory capacity of somatotroph cells. The possible use of Hex in chronic treatment to increase GH secretion and growth velocity could be also considered.
|Number of pages||5|
|Journal||Developmental Brain Dysfunction|
|Publication status||Published - 1996|
- Down syndrome
- Growth hormone
ASJC Scopus subject areas
- Clinical Neurology