Growth hormone releasing activity of hexarelin in Down syndrome

Letizia Ragusa; Antonino Alberti; Corrado Romano; Caterina Proto; Jaele Bellone; Fabio Colabucci; Bruno P. Imbimbo; Ezio Ghigo

Growth hormone releasing activity of hexarelin in Down syndrome

Letizia Ragusa, Antonino Alberti, Corrado Romano, Caterina Proto, Jaele Bellone, Fabio Colabucci, Bruno P. Imbimbo, Ezio Ghigo

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Abstract

Hexarelin (Hex) is a new synthetic GH-releasing peptide (GHRP) which has a potent dose-dependent stimulatory effect on GH secretion in man. The authors studied the GH secretion response in 12 subjects affected by Down syndrome (DS) following 2 μg/kg i.v. administration of Hex. The GH releasing effect was compared with that obtained after clonidine test (CT), insulin tolerance test (ITT), GH releasing hormone test (GHRH), and GHRH plus pyridostigmine (P) test. The results show that Hex is a potent GH stimulator in DS. Its response is similar to GHRH plus P and higher than CT, ITT, and even GHRH. Thus it may be useful for evaluating the secretory capacity of somatotroph cells. The possible use of Hex in chronic treatment to increase GH secretion and growth velocity could be also considered.

Original language	English
Pages (from-to)	133-137
Number of pages	5
Journal	Developmental Brain Dysfunction
Volume	9
Issue number	2-3
Publication status	Published - 1996

Keywords

Down syndrome
Growth hormone
Hexarelin

ASJC Scopus subject areas

Clinical Neurology
Neuroscience(all)

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title = "Growth hormone releasing activity of hexarelin in Down syndrome",

abstract = "Hexarelin (Hex) is a new synthetic GH-releasing peptide (GHRP) which has a potent dose-dependent stimulatory effect on GH secretion in man. The authors studied the GH secretion response in 12 subjects affected by Down syndrome (DS) following 2 μg/kg i.v. administration of Hex. The GH releasing effect was compared with that obtained after clonidine test (CT), insulin tolerance test (ITT), GH releasing hormone test (GHRH), and GHRH plus pyridostigmine (P) test. The results show that Hex is a potent GH stimulator in DS. Its response is similar to GHRH plus P and higher than CT, ITT, and even GHRH. Thus it may be useful for evaluating the secretory capacity of somatotroph cells. The possible use of Hex in chronic treatment to increase GH secretion and growth velocity could be also considered.",

keywords = "Down syndrome, Growth hormone, Hexarelin",

author = "Letizia Ragusa and Antonino Alberti and Corrado Romano and Caterina Proto and Jaele Bellone and Fabio Colabucci and Imbimbo, {Bruno P.} and Ezio Ghigo",

year = "1996",

language = "English",

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TY - JOUR

T1 - Growth hormone releasing activity of hexarelin in Down syndrome

AU - Ragusa, Letizia

AU - Alberti, Antonino

AU - Romano, Corrado

AU - Proto, Caterina

AU - Bellone, Jaele

AU - Colabucci, Fabio

AU - Imbimbo, Bruno P.

AU - Ghigo, Ezio

PY - 1996

Y1 - 1996

N2 - Hexarelin (Hex) is a new synthetic GH-releasing peptide (GHRP) which has a potent dose-dependent stimulatory effect on GH secretion in man. The authors studied the GH secretion response in 12 subjects affected by Down syndrome (DS) following 2 μg/kg i.v. administration of Hex. The GH releasing effect was compared with that obtained after clonidine test (CT), insulin tolerance test (ITT), GH releasing hormone test (GHRH), and GHRH plus pyridostigmine (P) test. The results show that Hex is a potent GH stimulator in DS. Its response is similar to GHRH plus P and higher than CT, ITT, and even GHRH. Thus it may be useful for evaluating the secretory capacity of somatotroph cells. The possible use of Hex in chronic treatment to increase GH secretion and growth velocity could be also considered.

AB - Hexarelin (Hex) is a new synthetic GH-releasing peptide (GHRP) which has a potent dose-dependent stimulatory effect on GH secretion in man. The authors studied the GH secretion response in 12 subjects affected by Down syndrome (DS) following 2 μg/kg i.v. administration of Hex. The GH releasing effect was compared with that obtained after clonidine test (CT), insulin tolerance test (ITT), GH releasing hormone test (GHRH), and GHRH plus pyridostigmine (P) test. The results show that Hex is a potent GH stimulator in DS. Its response is similar to GHRH plus P and higher than CT, ITT, and even GHRH. Thus it may be useful for evaluating the secretory capacity of somatotroph cells. The possible use of Hex in chronic treatment to increase GH secretion and growth velocity could be also considered.

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KW - Growth hormone

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