Growth hormone-releasing effects of whole body vibration alone or combined with squatting plus external load in severely obese female subjects

Marialuisa Giunta, Marco Cardinale, Fiorenza Agosti, Alessandra Patrizi, Emanuele Compri, Antonello E. Rigamonti, Alessandro Sartorio

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background: Whole body vibration (WBV) has been reported to exert growth hormone(GH)-releasing effects in healthy subjects. Despite the potential of WBV to positively affect body composition changes via lipolytic effects, few studies have been performed in obese subjects to date. Methods: This study evaluated the acute effects of WBV alone or in combination with squatting plus external load (WBV+S) on serum GH levels and blood lactate concentrations in 7 severely obese women (age 22 ± 5 years; BMI 39.9 ± 2.9 kg/m2). Results: WBV and WBV+S determined a significant GH increase (mean GH peaks 5.1 ± 1.9 ng/ml, p <0.001 vs. basal, and 6.5 ± 3.7 ng/ml, p <0.001 vs. basal, respectively), GH peaks occurring immediately after both exercise sessions. No significant differences were observed between GH peaks and GH net incremental area under the curve (nAUC) after both conditions (p = 0.39 and p = 0.53, respectively), the whole pattern of GH responsiveness being comparable among all the subjects. Lactate concentrations increased after both conditions (mean lactate peaks 2.0 ± 0.5 mmol/l, p <0.05 vs. basal, and 4.5 ± 2.0 mmol/l, p <0.001 vs. basal, respectively). The lactate response was significantly higher after WBV+S than after WBV (p <0.05). Baseline GH and GH peak values positively correlated to baseline lactate and lactate peak concentrations in both conditions (R2 = 0.64, p <0.001, and R2 = 0.52, p <0.05, respectively). Conclusions: WBV alone stimulates GH release and lactate production in severely obese female subjects, with no additive effect when combined with squatting plus external load. Further additional studies are required to verify the chronic effects of WBV exercise on the GH/IGF-1 system, which could represent a potentially effective approach for weight management in obese subjects.

Original languageEnglish
Pages (from-to)567-574
Number of pages8
JournalObesity Facts
Volume5
Issue number4
DOIs
Publication statusPublished - Sep 2012

Fingerprint

Vibration
Growth Hormone
Lactic Acid
Exercise
Body Composition
Insulin-Like Growth Factor I
Area Under Curve
Healthy Volunteers
Weights and Measures

Keywords

  • Growth hormone
  • Lactate
  • Obesity
  • Squatting
  • Whole body vibration

ASJC Scopus subject areas

  • Physiology (medical)
  • Health(social science)

Cite this

Growth hormone-releasing effects of whole body vibration alone or combined with squatting plus external load in severely obese female subjects. / Giunta, Marialuisa; Cardinale, Marco; Agosti, Fiorenza; Patrizi, Alessandra; Compri, Emanuele; Rigamonti, Antonello E.; Sartorio, Alessandro.

In: Obesity Facts, Vol. 5, No. 4, 09.2012, p. 567-574.

Research output: Contribution to journalArticle

Giunta, Marialuisa ; Cardinale, Marco ; Agosti, Fiorenza ; Patrizi, Alessandra ; Compri, Emanuele ; Rigamonti, Antonello E. ; Sartorio, Alessandro. / Growth hormone-releasing effects of whole body vibration alone or combined with squatting plus external load in severely obese female subjects. In: Obesity Facts. 2012 ; Vol. 5, No. 4. pp. 567-574.
@article{74db9635eb8240c2bee50e509cbaff15,
title = "Growth hormone-releasing effects of whole body vibration alone or combined with squatting plus external load in severely obese female subjects",
abstract = "Background: Whole body vibration (WBV) has been reported to exert growth hormone(GH)-releasing effects in healthy subjects. Despite the potential of WBV to positively affect body composition changes via lipolytic effects, few studies have been performed in obese subjects to date. Methods: This study evaluated the acute effects of WBV alone or in combination with squatting plus external load (WBV+S) on serum GH levels and blood lactate concentrations in 7 severely obese women (age 22 ± 5 years; BMI 39.9 ± 2.9 kg/m2). Results: WBV and WBV+S determined a significant GH increase (mean GH peaks 5.1 ± 1.9 ng/ml, p <0.001 vs. basal, and 6.5 ± 3.7 ng/ml, p <0.001 vs. basal, respectively), GH peaks occurring immediately after both exercise sessions. No significant differences were observed between GH peaks and GH net incremental area under the curve (nAUC) after both conditions (p = 0.39 and p = 0.53, respectively), the whole pattern of GH responsiveness being comparable among all the subjects. Lactate concentrations increased after both conditions (mean lactate peaks 2.0 ± 0.5 mmol/l, p <0.05 vs. basal, and 4.5 ± 2.0 mmol/l, p <0.001 vs. basal, respectively). The lactate response was significantly higher after WBV+S than after WBV (p <0.05). Baseline GH and GH peak values positively correlated to baseline lactate and lactate peak concentrations in both conditions (R2 = 0.64, p <0.001, and R2 = 0.52, p <0.05, respectively). Conclusions: WBV alone stimulates GH release and lactate production in severely obese female subjects, with no additive effect when combined with squatting plus external load. Further additional studies are required to verify the chronic effects of WBV exercise on the GH/IGF-1 system, which could represent a potentially effective approach for weight management in obese subjects.",
keywords = "Growth hormone, Lactate, Obesity, Squatting, Whole body vibration",
author = "Marialuisa Giunta and Marco Cardinale and Fiorenza Agosti and Alessandra Patrizi and Emanuele Compri and Rigamonti, {Antonello E.} and Alessandro Sartorio",
year = "2012",
month = "9",
doi = "10.1159/000342066",
language = "English",
volume = "5",
pages = "567--574",
journal = "Obesity Facts",
issn = "1662-4025",
publisher = "S. Karger AG",
number = "4",

}

TY - JOUR

T1 - Growth hormone-releasing effects of whole body vibration alone or combined with squatting plus external load in severely obese female subjects

AU - Giunta, Marialuisa

AU - Cardinale, Marco

AU - Agosti, Fiorenza

AU - Patrizi, Alessandra

AU - Compri, Emanuele

AU - Rigamonti, Antonello E.

AU - Sartorio, Alessandro

PY - 2012/9

Y1 - 2012/9

N2 - Background: Whole body vibration (WBV) has been reported to exert growth hormone(GH)-releasing effects in healthy subjects. Despite the potential of WBV to positively affect body composition changes via lipolytic effects, few studies have been performed in obese subjects to date. Methods: This study evaluated the acute effects of WBV alone or in combination with squatting plus external load (WBV+S) on serum GH levels and blood lactate concentrations in 7 severely obese women (age 22 ± 5 years; BMI 39.9 ± 2.9 kg/m2). Results: WBV and WBV+S determined a significant GH increase (mean GH peaks 5.1 ± 1.9 ng/ml, p <0.001 vs. basal, and 6.5 ± 3.7 ng/ml, p <0.001 vs. basal, respectively), GH peaks occurring immediately after both exercise sessions. No significant differences were observed between GH peaks and GH net incremental area under the curve (nAUC) after both conditions (p = 0.39 and p = 0.53, respectively), the whole pattern of GH responsiveness being comparable among all the subjects. Lactate concentrations increased after both conditions (mean lactate peaks 2.0 ± 0.5 mmol/l, p <0.05 vs. basal, and 4.5 ± 2.0 mmol/l, p <0.001 vs. basal, respectively). The lactate response was significantly higher after WBV+S than after WBV (p <0.05). Baseline GH and GH peak values positively correlated to baseline lactate and lactate peak concentrations in both conditions (R2 = 0.64, p <0.001, and R2 = 0.52, p <0.05, respectively). Conclusions: WBV alone stimulates GH release and lactate production in severely obese female subjects, with no additive effect when combined with squatting plus external load. Further additional studies are required to verify the chronic effects of WBV exercise on the GH/IGF-1 system, which could represent a potentially effective approach for weight management in obese subjects.

AB - Background: Whole body vibration (WBV) has been reported to exert growth hormone(GH)-releasing effects in healthy subjects. Despite the potential of WBV to positively affect body composition changes via lipolytic effects, few studies have been performed in obese subjects to date. Methods: This study evaluated the acute effects of WBV alone or in combination with squatting plus external load (WBV+S) on serum GH levels and blood lactate concentrations in 7 severely obese women (age 22 ± 5 years; BMI 39.9 ± 2.9 kg/m2). Results: WBV and WBV+S determined a significant GH increase (mean GH peaks 5.1 ± 1.9 ng/ml, p <0.001 vs. basal, and 6.5 ± 3.7 ng/ml, p <0.001 vs. basal, respectively), GH peaks occurring immediately after both exercise sessions. No significant differences were observed between GH peaks and GH net incremental area under the curve (nAUC) after both conditions (p = 0.39 and p = 0.53, respectively), the whole pattern of GH responsiveness being comparable among all the subjects. Lactate concentrations increased after both conditions (mean lactate peaks 2.0 ± 0.5 mmol/l, p <0.05 vs. basal, and 4.5 ± 2.0 mmol/l, p <0.001 vs. basal, respectively). The lactate response was significantly higher after WBV+S than after WBV (p <0.05). Baseline GH and GH peak values positively correlated to baseline lactate and lactate peak concentrations in both conditions (R2 = 0.64, p <0.001, and R2 = 0.52, p <0.05, respectively). Conclusions: WBV alone stimulates GH release and lactate production in severely obese female subjects, with no additive effect when combined with squatting plus external load. Further additional studies are required to verify the chronic effects of WBV exercise on the GH/IGF-1 system, which could represent a potentially effective approach for weight management in obese subjects.

KW - Growth hormone

KW - Lactate

KW - Obesity

KW - Squatting

KW - Whole body vibration

UR - http://www.scopus.com/inward/record.url?scp=84865306147&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84865306147&partnerID=8YFLogxK

U2 - 10.1159/000342066

DO - 10.1159/000342066

M3 - Article

C2 - 22922806

AN - SCOPUS:84865306147

VL - 5

SP - 567

EP - 574

JO - Obesity Facts

JF - Obesity Facts

SN - 1662-4025

IS - 4

ER -