Growth hormone response to growth hormone-releasing hormone stimulation in obsessive-compulsive disorder

Francesca Brambilla, Laura Bellodi, Giampaolo Perna, Cinzia Arancio, Angelo Bertani

Research output: Contribution to journalArticlepeer-review

Abstract

Two groups of 30 patients with obsessive-compulsive disorder and 30 age- and sex-matched healthy control subjects were given a growth hormone- releasing hormone (GHRH) stimulation test to determine: (1) whether the downstream function of the somatotropic axis (growth hormone = GH, somatomedin-C = SMD-C) was impaired; (2) what might be the central alteration responsible for such impairment; and (3) whether alterations might be linked to the etiopathogenesis of the disease. Basal values of GH and SMD-C were the same in patients and control subjects, but GH responses to GHRH stimulation were significantly lower in patients than in control subjects. The absence of a pathology of basal GH and SMD-C concentrations indicates that the blunted GH responses to GHRH stimulation are not due to a negative feedback mechanism and suggests that a central neurotransmitter-neuropeptide pathology might be involved in the phenomenon.

Original languageEnglish
Pages (from-to)293-299
Number of pages7
JournalPsychiatry Research
Volume81
Issue number3
DOIs
Publication statusPublished - Dec 14 1998

Keywords

  • Endocrine factors
  • Obsessive compulsive disorder
  • Somatomedin-C
  • Somatotropic axis

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

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