Growth hormone secretion after baclofen administration in different phases of the menstrual cycle in healthy women

F. Orio, S. Palomba, A. Colao, M. Tenuta, C. Dentico, M. Petretta, G. Lombardi, C. Nappi, Francesco Orio

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: The aim of this study was to investigate the effect of baclofen administration on growth hormone (GH) secretion during different phases of the menstrual cycle. Methods: Twelve healthy women (33.6 ± (SD) 2.8 years; range 23-40 years) with regular menstrual cycles were enrolled. The phases of the menstrual cycle were determined using transvaginal ultrasonography (TV-US) and detecting hormonal serum levels. Plasma GH levels were evaluated during the early follicular, periovulatory and luteal phases of the cycle before and after the baclofen challenge test. Results: After acute baclofen administration, GH levels increased significantly (p <0.001) compared to basal values during the periovulatory and luteal phases, while no significant variation was detected during the early follicular phase. In addition, plasma GH levels resulted significantly (p <0.001) higher during the luteal phase than during the periovulatory phase. Conclusion: Acute baclofen administration induces a significant increase in plasma GH levels in healthy females during the periovulatory and luteal phases, but not during the early follicular phase. These data suggest a modulator role of plasma sex steroids levels on GH release induced by baclofen.

Original languageEnglish
Pages (from-to)131-136
Number of pages6
JournalHormone Research
Volume55
Issue number3
DOIs
Publication statusPublished - 2001

Keywords

  • Baclofen
  • GABA
  • Growth hormone
  • Sex hormones

ASJC Scopus subject areas

  • Endocrinology

Fingerprint

Dive into the research topics of 'Growth hormone secretion after baclofen administration in different phases of the menstrual cycle in healthy women'. Together they form a unique fingerprint.

Cite this