Growth Hormone Secretion in Noonan's Syndrome

S. Bernardini, G. L. Spadoni, S. Cianfarani, F. Vaccaro, A. M. Pasquino, B. Boscherini

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Abstract

Growth hormone (GH) secretion was studied in eight children with Noonan’s syndrome: while GH response to pharmacologic stimulation was normal in all subjects, low spontaneous nocturnal GH secretion and/or low levels of IGF-1 were found in some patients. Two children received GH therapy for six months: a significative increase in height velocity was observed and no side effects were noted.

Original languageEnglish
Pages (from-to)217-222
Number of pages6
JournalJournal of Pediatric Endocrinology and Metabolism
Volume4
Issue number4
DOIs
Publication statusPublished - 1991

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Keywords

  • Noonan's
  • syndrome growth hormone

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Pediatrics, Perinatology, and Child Health

Cite this

Bernardini, S., Spadoni, G. L., Cianfarani, S., Vaccaro, F., Pasquino, A. M., & Boscherini, B. (1991). Growth Hormone Secretion in Noonan's Syndrome. Journal of Pediatric Endocrinology and Metabolism, 4(4), 217-222. https://doi.org/10.1515/JPEM.1991.4.4.217