Growth hormone (GH) secretion was studied in eight children with Noonan’s syndrome: while GH response to pharmacologic stimulation was normal in all subjects, low spontaneous nocturnal GH secretion and/or low levels of IGF-1 were found in some patients. Two children received GH therapy for six months: a significative increase in height velocity was observed and no side effects were noted.
- syndrome growth hormone
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Pediatrics, Perinatology, and Child Health