Growth hormone therapy does not alter the insulin-like growth factor-I/insulin-like growth factor binding protein-3 molar ratio in growth hormone-deficient children

G. Scirè, C. Del Bianco, G. L. Spadoni, Stefano Cianfarani

Research output: Contribution to journalArticle

Abstract

Background: Recent studies have linked raised levels of IGF-I and/or reduced levels of its main binding protein, IGF binding protein (IGFBP)-3, with the risk of developing cancer. A GH dose-dependent increase in IGF-I/IGFBP-3 molar ratio has been reported in subjects treated with GH, raising concern about the long-term safety. Objective: The aim of this study was to evaluate changes in serum IGF-I, IGFBP-3, and IGF-I/IGFBP-3 molar ratio over the first 12 months of replacement GH therapy in GH deficient (GHD) children. Methods: The study included 20 GHD children who had not previously received GH treatment, and 40 untreated non-GHD short children closely matched for age, gender, pubertal stage, and body mass index (BMI), as controls. Serum IGF-I, IGFBP-3 levels were measured before and after 12 months of GH treatment. Based on the molecular weight of IGF-I (7500) and IGF-BP-3 (40,000, mean of glycosylated variants), we calculated the molar ratio of IGF-I/IGFBP-3. Results: IGF-I/IGFBP-3 molar ratio significantly increased during GH therapy (p=0.01). No significant difference in IGF-I/IGFBP-3 ratio was found between GHD children and controls at the different time points. In the multiple regression analysis, BMI (β=0.33) and age (β=0.33) proved to be the major predictors of the IGF-I/IGFBP-3 molar ratio (adjusted r 2=0.53, p

Original languageEnglish
Pages (from-to)153-158
Number of pages6
JournalJournal of Endocrinological Investigation
Volume31
Issue number2
Publication statusPublished - Feb 2008

Keywords

  • GH deficiency
  • GH therapy
  • IGF-1
  • IGFBP-3

ASJC Scopus subject areas

  • Endocrinology

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