Growth hormone therapy improves exercise capacity in adult patients with Prader-Willi syndrome

L. A. Gondoni, L. Vismara, P. Marzullo, R. Vettor, A. Liuzzi, G. Grugni

Research output: Contribution to journalArticle


Background: Prader-Willi syndrome (PWS) is associated with an inappropriate proportion of fat mass (FM) to non-FM compared to simple obesity. Altered body composition in PWS resembles that seen in subjects with GH deficiency, in which a reduction of lean body mass (LBM) is observed. The low-LBM may contribute to the reduced motor skills seen in PWS patients. Aim: The objective of the study was to investigate the effects of GH therapy on exercise capacity and body composition in a group of adult subjects with PWS. Subjects and methods: Twelve PWS adults (7 males and 5 females, aged 26.4±4.4 yr, body mass index 44.3±4.6 kg/m2) participated in the study. Body composition analysis and exercise stress test were carried out throughout the 12 months GH therapy. Body composition was measured by Dual Energy X-ray Absorptiometry. Physical performance was evaluated using treadmill exercise test. Exercise intensity was expressed as metabolic equivalents (MET, 1 MET= 3.5 ml O2 kg-1min-1). Statistical analysis was performed by repeated-measures analysis of variance followed by post-hoc analysis with t test for paired data for comparisons among the different follow ups. Results: Compared to baseline GH therapy increased LBM at 6 (p

Original languageEnglish
Pages (from-to)765-772
Number of pages8
JournalJournal of Endocrinological Investigation
Issue number9
Publication statusPublished - Sep 2008


  • Adults
  • Body composition
  • Exercise
  • GH therapy
  • Prader-Willi syndrome

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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