Growth hormone treatment in Noonan syndrome: Report of four cases who reached final height

G. Municchi, A. M. Pasquino, I. Pucarelli, S. Cianfarani, F. Passeri

Research output: Contribution to journalArticlepeer-review

Abstract

Final height of 4 patients with Noonan syndrome and short stature treated with growth hormone (GH) is reported. Four prepubertal girls (chronological age 12.3-15.1 years, bone age 11.0-11.5 years) were treated with recombinant human growth hormone (0.5 IU/kg/week s.c.) for at least 3 years. Stimulated GH secretion was normal, spontaneous nocturnal GH secretion was low in 1 patient. Final height, as standard deviation score according to Ranke-specific standards for Noonan syndrome, improved in 3 patients and 2 of them exceeded their corrected midparental height.

Original languageEnglish
Pages (from-to)164-167
Number of pages4
JournalHormone Research
Volume44
Issue number4
Publication statusPublished - 1995

Keywords

  • Final height
  • Human growth hormone
  • Noonan syndrome

ASJC Scopus subject areas

  • Endocrinology

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