Abstract
Final height of 4 patients with Noonan syndrome and short stature treated with growth hormone (GH) is reported. Four prepubertal girls (chronological age 12.3-15.1 years, bone age 11.0-11.5 years) were treated with recombinant human growth hormone (0.5 IU/kg/week s.c.) for at least 3 years. Stimulated GH secretion was normal, spontaneous nocturnal GH secretion was low in 1 patient. Final height, as standard deviation score according to Ranke-specific standards for Noonan syndrome, improved in 3 patients and 2 of them exceeded their corrected midparental height.
Original language | English |
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Pages (from-to) | 164-167 |
Number of pages | 4 |
Journal | Hormone Research |
Volume | 44 |
Issue number | 4 |
Publication status | Published - 1995 |
Keywords
- Final height
- Human growth hormone
- Noonan syndrome
ASJC Scopus subject areas
- Endocrinology