Growth hormone treatment in Noonan syndrome: Report of four cases who reached final height

G. Municchi; A. M. Pasquino; I. Pucarelli; S. Cianfarani; F. Passeri

Growth hormone treatment in Noonan syndrome: Report of four cases who reached final height

G. Municchi, A. M. Pasquino, I. Pucarelli, S. Cianfarani, F. Passeri

Ospedale Pediatrico Bambino Gesu

Research output: Contribution to journal › Article › peer-review

Abstract

Final height of 4 patients with Noonan syndrome and short stature treated with growth hormone (GH) is reported. Four prepubertal girls (chronological age 12.3-15.1 years, bone age 11.0-11.5 years) were treated with recombinant human growth hormone (0.5 IU/kg/week s.c.) for at least 3 years. Stimulated GH secretion was normal, spontaneous nocturnal GH secretion was low in 1 patient. Final height, as standard deviation score according to Ranke-specific standards for Noonan syndrome, improved in 3 patients and 2 of them exceeded their corrected midparental height.

Original language	English
Pages (from-to)	164-167
Number of pages	4
Journal	Hormone Research
Volume	44
Issue number	4
Publication status	Published - 1995

Keywords

Final height
Human growth hormone
Noonan syndrome

ASJC Scopus subject areas

Endocrinology

Fingerprint Dive into the research topics of 'Growth hormone treatment in Noonan syndrome: Report of four cases who reached final height'. Together they form a unique fingerprint.

Cite this

@article{938720f4467045659e1ec22acb5795b1,

title = "Growth hormone treatment in Noonan syndrome: Report of four cases who reached final height",

abstract = "Final height of 4 patients with Noonan syndrome and short stature treated with growth hormone (GH) is reported. Four prepubertal girls (chronological age 12.3-15.1 years, bone age 11.0-11.5 years) were treated with recombinant human growth hormone (0.5 IU/kg/week s.c.) for at least 3 years. Stimulated GH secretion was normal, spontaneous nocturnal GH secretion was low in 1 patient. Final height, as standard deviation score according to Ranke-specific standards for Noonan syndrome, improved in 3 patients and 2 of them exceeded their corrected midparental height.",

keywords = "Final height, Human growth hormone, Noonan syndrome",

author = "G. Municchi and Pasquino, {A. M.} and I. Pucarelli and S. Cianfarani and F. Passeri",

year = "1995",

language = "English",

volume = "44",

pages = "164--167",

journal = "Hormone Research",

issn = "0301-0163",

publisher = "S. Karger AG",

number = "4",

}

TY - JOUR

T1 - Growth hormone treatment in Noonan syndrome

T2 - Report of four cases who reached final height

AU - Municchi, G.

AU - Pasquino, A. M.

AU - Pucarelli, I.

AU - Cianfarani, S.

AU - Passeri, F.

PY - 1995

Y1 - 1995

N2 - Final height of 4 patients with Noonan syndrome and short stature treated with growth hormone (GH) is reported. Four prepubertal girls (chronological age 12.3-15.1 years, bone age 11.0-11.5 years) were treated with recombinant human growth hormone (0.5 IU/kg/week s.c.) for at least 3 years. Stimulated GH secretion was normal, spontaneous nocturnal GH secretion was low in 1 patient. Final height, as standard deviation score according to Ranke-specific standards for Noonan syndrome, improved in 3 patients and 2 of them exceeded their corrected midparental height.

AB - Final height of 4 patients with Noonan syndrome and short stature treated with growth hormone (GH) is reported. Four prepubertal girls (chronological age 12.3-15.1 years, bone age 11.0-11.5 years) were treated with recombinant human growth hormone (0.5 IU/kg/week s.c.) for at least 3 years. Stimulated GH secretion was normal, spontaneous nocturnal GH secretion was low in 1 patient. Final height, as standard deviation score according to Ranke-specific standards for Noonan syndrome, improved in 3 patients and 2 of them exceeded their corrected midparental height.

KW - Final height

KW - Human growth hormone

KW - Noonan syndrome

UR - http://www.scopus.com/inward/record.url?scp=0029165302&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029165302&partnerID=8YFLogxK

M3 - Article

C2 - 8522277

AN - SCOPUS:0029165302

VL - 44

SP - 164

EP - 167

JO - Hormone Research

JF - Hormone Research

SN - 0301-0163

IS - 4

ER -

Growth hormone treatment in Noonan syndrome: Report of four cases who reached final height

Abstract

Keywords

ASJC Scopus subject areas

Other files and links

Cite this