Growth hormone treatment prevents loss of lean mass after bariatric surgery in morbidly obese Patients: Results of a pilot, open, prospective, randomized, controlled study

Silvia Savastano, Carolina Di Somma, Luigi Angrisani, Francesco Orio, Salvatore Longobardi, Gaetano Lombardi, Annamaria Colao

Research output: Contribution to journalArticle

Abstract

Context: The loss of lean body mass (LBM) negatively influences the outcome in bariatric surgery. Impaired GH secretion is frequent in obese patients. Objective: Our objective was to investigate if GH treatment prevents LBM loss in the early postoperative period. Design: This was an open, prospective, randomized, and controlled study. Patients: A total of 24 women (body mass index: 44.4 ± 7.6 kg/m2, aged 36.8 ± 11.7yr) undergoing laparoscopic-adjustable silicone gastric banding (LASGB) and with GH deficiency after LASGB was included in the study. Treatment Protocol: Group A (n = 12) included a standardized diet regimen and exercise program plus recombinant human GH (0.5 ± 0.13 mg every day), and group B (n = 12) included a standardized diet regimen and exercise program. The follow-up duration was 6 months. Results: The excess of body weight loss did not differ between groups A and B after 3 and 6 months. At 3 months, LBM loss was lower (P <0.0001) and fat mass (FM) loss was higher (P = 0.02) in group A than group B. At 3 and 6 months, appendicular skeletal muscle mass loss was lower (P = 0.000) in group A than group B. At 3 (P = 0.0003 and 0.0005, respectively) and 6 months (P <0.0001 and 0.0002, respectively), the percent changes of FM and lean body mass were significantly higher in group A than group B. In both groups fasting and postglucose area under the plasma concentration-time curve insulin significantly reduced. The homeostasis model assessment of insulin and insulin sensitivity indexes and total to high-density lipoprotein cholesterol ratio improved only in group A. Conclusions: GH treatment for 6 months after LASGB reduces loss in LBM and appendicular skeletal muscle mass during a standardized program of low-calorie diet and physical exercise program, with improvement of lipid profile and without a deterioration of glucose tolerance.

Original languageEnglish
Pages (from-to)817-826
Number of pages10
JournalJournal of Clinical Endocrinology and Metabolism
Volume94
Issue number3
DOIs
Publication statusPublished - Mar 2009

    Fingerprint

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism

Cite this