Growth hormone variants: A potential avenue for a better diagnostic characterization of growth hormone deficiency in children

A. E. Rigamonti, M. Bozzola, G. Banfi, C. Meazza, E. E. Müller, S. G. Cella

Research output: Contribution to journalArticlepeer-review

Abstract

Human GH (hGH) is a heterogeneous protein hormone consisting of several isoforms. This heterogeneity is the consequence of multiple hGH genes, mRNA splicing, post-translational modifications, and peripheral metabolism, and it represents one important reason for the disparity among GH assay results from different laboratories. However, other factors are involved: a) interference from endogenous GH binding proteins; b) different specificities of anti- GH (monoclonal and polyclonal) antibodies; c) different matrix effects among the calibrators; d) the use of different calibrators. The measurement of GH levels in response to provocative testing is an essential part of the diagnosis of GH deficiency. For this purpose, an accurate, reproducible and universally valid GH measurement would be highly desirable, but, despite a huge number of efforts in clinical biochemistry, this goal remains elusive.

Original languageEnglish
Pages (from-to)937-944
Number of pages8
JournalJournal of Endocrinological Investigation
Volume35
Issue number10
DOIs
Publication statusPublished - Nov 2012

Keywords

  • Analytical methods
  • Biochemical diagnosis
  • GH deficiency
  • GH isoforms
  • Growth hormone

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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