Growth impairment and growth hormone-IGF-1 axis in infantile anorexia nervosa

Silvia Ghione, Sandra Maestro, Eleonora Dati, Virginia Silvestri, Giampiero I. Baroncelli, Silvano Bertelloni

Research output: Contribution to journalArticle

Abstract

Background: Infantile anorexia nervosa (AN) is a specific eating disorder of prepubertal children. Poor data are available on growth hormone (GH)-insulin-like growth factor 1 (IGF-1) axis in this disorder. Patient report: We report on a boy (4.5 years) with progressive growth impairment. At psychiatric assessment (DC: 0-3 R, AXIS I), he fulfilled all required criteria for diagnosis of infantile AN. Endocrine evaluation suggested impaired peripheral response to GH (high GH and low IGF-1 levels), likely related to energy deficiency. Methods: Auxological evaluation was shown as raw data and SDS using Italian reference values. GH secretion was assessed by arginine provocative test; IGFI generation test was done administering recombinant GH (0.05 mg/kg/day for four days). Psychiatric assessment was performed according to the DC:0-3R protocol. Conclusion: Impaired GH-IGF-1 axis may be involved in growth delay of children with infantile AN. A strict collaboration between endocrine pediatricians and child psychiatrists is advisable in the assessment of poor growing children without recognizable organic causes, showing normal/high GH levels and low IGF-1 values.

Original languageEnglish
Pages (from-to)999-1001
Number of pages3
JournalJournal of Pediatric Endocrinology and Metabolism
Volume28
Issue number9-10
DOIs
Publication statusPublished - Sep 1 2015

Fingerprint

Anorexia Nervosa
Somatomedins
Growth Hormone
Growth
Psychiatry
Arginine
Reference Values

Keywords

  • growth
  • growth hormone
  • IGF-1
  • infantile anorexia nervosa
  • prepubertal eating disorders

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Pediatrics, Perinatology, and Child Health

Cite this

Growth impairment and growth hormone-IGF-1 axis in infantile anorexia nervosa. / Ghione, Silvia; Maestro, Sandra; Dati, Eleonora; Silvestri, Virginia; Baroncelli, Giampiero I.; Bertelloni, Silvano.

In: Journal of Pediatric Endocrinology and Metabolism, Vol. 28, No. 9-10, 01.09.2015, p. 999-1001.

Research output: Contribution to journalArticle

Ghione, Silvia ; Maestro, Sandra ; Dati, Eleonora ; Silvestri, Virginia ; Baroncelli, Giampiero I. ; Bertelloni, Silvano. / Growth impairment and growth hormone-IGF-1 axis in infantile anorexia nervosa. In: Journal of Pediatric Endocrinology and Metabolism. 2015 ; Vol. 28, No. 9-10. pp. 999-1001.
@article{ac9450e1ac894bcda294f4ea2f24b226,
title = "Growth impairment and growth hormone-IGF-1 axis in infantile anorexia nervosa",
abstract = "Background: Infantile anorexia nervosa (AN) is a specific eating disorder of prepubertal children. Poor data are available on growth hormone (GH)-insulin-like growth factor 1 (IGF-1) axis in this disorder. Patient report: We report on a boy (4.5 years) with progressive growth impairment. At psychiatric assessment (DC: 0-3 R, AXIS I), he fulfilled all required criteria for diagnosis of infantile AN. Endocrine evaluation suggested impaired peripheral response to GH (high GH and low IGF-1 levels), likely related to energy deficiency. Methods: Auxological evaluation was shown as raw data and SDS using Italian reference values. GH secretion was assessed by arginine provocative test; IGFI generation test was done administering recombinant GH (0.05 mg/kg/day for four days). Psychiatric assessment was performed according to the DC:0-3R protocol. Conclusion: Impaired GH-IGF-1 axis may be involved in growth delay of children with infantile AN. A strict collaboration between endocrine pediatricians and child psychiatrists is advisable in the assessment of poor growing children without recognizable organic causes, showing normal/high GH levels and low IGF-1 values.",
keywords = "growth, growth hormone, IGF-1, infantile anorexia nervosa, prepubertal eating disorders",
author = "Silvia Ghione and Sandra Maestro and Eleonora Dati and Virginia Silvestri and Baroncelli, {Giampiero I.} and Silvano Bertelloni",
year = "2015",
month = "9",
day = "1",
doi = "10.1515/jpem-2013-0400",
language = "English",
volume = "28",
pages = "999--1001",
journal = "Journal of Pediatric Endocrinology and Metabolism",
issn = "0334-018X",
publisher = "Walter de Gruyter GmbH & Co. KG",
number = "9-10",

}

TY - JOUR

T1 - Growth impairment and growth hormone-IGF-1 axis in infantile anorexia nervosa

AU - Ghione, Silvia

AU - Maestro, Sandra

AU - Dati, Eleonora

AU - Silvestri, Virginia

AU - Baroncelli, Giampiero I.

AU - Bertelloni, Silvano

PY - 2015/9/1

Y1 - 2015/9/1

N2 - Background: Infantile anorexia nervosa (AN) is a specific eating disorder of prepubertal children. Poor data are available on growth hormone (GH)-insulin-like growth factor 1 (IGF-1) axis in this disorder. Patient report: We report on a boy (4.5 years) with progressive growth impairment. At psychiatric assessment (DC: 0-3 R, AXIS I), he fulfilled all required criteria for diagnosis of infantile AN. Endocrine evaluation suggested impaired peripheral response to GH (high GH and low IGF-1 levels), likely related to energy deficiency. Methods: Auxological evaluation was shown as raw data and SDS using Italian reference values. GH secretion was assessed by arginine provocative test; IGFI generation test was done administering recombinant GH (0.05 mg/kg/day for four days). Psychiatric assessment was performed according to the DC:0-3R protocol. Conclusion: Impaired GH-IGF-1 axis may be involved in growth delay of children with infantile AN. A strict collaboration between endocrine pediatricians and child psychiatrists is advisable in the assessment of poor growing children without recognizable organic causes, showing normal/high GH levels and low IGF-1 values.

AB - Background: Infantile anorexia nervosa (AN) is a specific eating disorder of prepubertal children. Poor data are available on growth hormone (GH)-insulin-like growth factor 1 (IGF-1) axis in this disorder. Patient report: We report on a boy (4.5 years) with progressive growth impairment. At psychiatric assessment (DC: 0-3 R, AXIS I), he fulfilled all required criteria for diagnosis of infantile AN. Endocrine evaluation suggested impaired peripheral response to GH (high GH and low IGF-1 levels), likely related to energy deficiency. Methods: Auxological evaluation was shown as raw data and SDS using Italian reference values. GH secretion was assessed by arginine provocative test; IGFI generation test was done administering recombinant GH (0.05 mg/kg/day for four days). Psychiatric assessment was performed according to the DC:0-3R protocol. Conclusion: Impaired GH-IGF-1 axis may be involved in growth delay of children with infantile AN. A strict collaboration between endocrine pediatricians and child psychiatrists is advisable in the assessment of poor growing children without recognizable organic causes, showing normal/high GH levels and low IGF-1 values.

KW - growth

KW - growth hormone

KW - IGF-1

KW - infantile anorexia nervosa

KW - prepubertal eating disorders

UR - http://www.scopus.com/inward/record.url?scp=84941057253&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84941057253&partnerID=8YFLogxK

U2 - 10.1515/jpem-2013-0400

DO - 10.1515/jpem-2013-0400

M3 - Article

C2 - 25153569

AN - SCOPUS:84941057253

VL - 28

SP - 999

EP - 1001

JO - Journal of Pediatric Endocrinology and Metabolism

JF - Journal of Pediatric Endocrinology and Metabolism

SN - 0334-018X

IS - 9-10

ER -