Abstract
Background: Infantile anorexia nervosa (AN) is a specific eating disorder of prepubertal children. Poor data are available on growth hormone (GH)-insulin-like growth factor 1 (IGF-1) axis in this disorder. Patient report: We report on a boy (4.5 years) with progressive growth impairment. At psychiatric assessment (DC: 0-3 R, AXIS I), he fulfilled all required criteria for diagnosis of infantile AN. Endocrine evaluation suggested impaired peripheral response to GH (high GH and low IGF-1 levels), likely related to energy deficiency. Methods: Auxological evaluation was shown as raw data and SDS using Italian reference values. GH secretion was assessed by arginine provocative test; IGFI generation test was done administering recombinant GH (0.05 mg/kg/day for four days). Psychiatric assessment was performed according to the DC:0-3R protocol. Conclusion: Impaired GH-IGF-1 axis may be involved in growth delay of children with infantile AN. A strict collaboration between endocrine pediatricians and child psychiatrists is advisable in the assessment of poor growing children without recognizable organic causes, showing normal/high GH levels and low IGF-1 values.
| Original language | English |
|---|---|
| Pages (from-to) | 999-1001 |
| Number of pages | 3 |
| Journal | Journal of Pediatric Endocrinology and Metabolism |
| Volume | 28 |
| Issue number | 9-10 |
| DOIs | |
| Publication status | Published - Sep 1 2015 |
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Keywords
- growth
- growth hormone
- IGF-1
- infantile anorexia nervosa
- prepubertal eating disorders
ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism
- Pediatrics, Perinatology, and Child Health
Cite this
Growth impairment and growth hormone-IGF-1 axis in infantile anorexia nervosa. / Ghione, Silvia; Maestro, Sandra; Dati, Eleonora; Silvestri, Virginia; Baroncelli, Giampiero I.; Bertelloni, Silvano.
In: Journal of Pediatric Endocrinology and Metabolism, Vol. 28, No. 9-10, 01.09.2015, p. 999-1001.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Growth impairment and growth hormone-IGF-1 axis in infantile anorexia nervosa
AU - Ghione, Silvia
AU - Maestro, Sandra
AU - Dati, Eleonora
AU - Silvestri, Virginia
AU - Baroncelli, Giampiero I.
AU - Bertelloni, Silvano
PY - 2015/9/1
Y1 - 2015/9/1
N2 - Background: Infantile anorexia nervosa (AN) is a specific eating disorder of prepubertal children. Poor data are available on growth hormone (GH)-insulin-like growth factor 1 (IGF-1) axis in this disorder. Patient report: We report on a boy (4.5 years) with progressive growth impairment. At psychiatric assessment (DC: 0-3 R, AXIS I), he fulfilled all required criteria for diagnosis of infantile AN. Endocrine evaluation suggested impaired peripheral response to GH (high GH and low IGF-1 levels), likely related to energy deficiency. Methods: Auxological evaluation was shown as raw data and SDS using Italian reference values. GH secretion was assessed by arginine provocative test; IGFI generation test was done administering recombinant GH (0.05 mg/kg/day for four days). Psychiatric assessment was performed according to the DC:0-3R protocol. Conclusion: Impaired GH-IGF-1 axis may be involved in growth delay of children with infantile AN. A strict collaboration between endocrine pediatricians and child psychiatrists is advisable in the assessment of poor growing children without recognizable organic causes, showing normal/high GH levels and low IGF-1 values.
AB - Background: Infantile anorexia nervosa (AN) is a specific eating disorder of prepubertal children. Poor data are available on growth hormone (GH)-insulin-like growth factor 1 (IGF-1) axis in this disorder. Patient report: We report on a boy (4.5 years) with progressive growth impairment. At psychiatric assessment (DC: 0-3 R, AXIS I), he fulfilled all required criteria for diagnosis of infantile AN. Endocrine evaluation suggested impaired peripheral response to GH (high GH and low IGF-1 levels), likely related to energy deficiency. Methods: Auxological evaluation was shown as raw data and SDS using Italian reference values. GH secretion was assessed by arginine provocative test; IGFI generation test was done administering recombinant GH (0.05 mg/kg/day for four days). Psychiatric assessment was performed according to the DC:0-3R protocol. Conclusion: Impaired GH-IGF-1 axis may be involved in growth delay of children with infantile AN. A strict collaboration between endocrine pediatricians and child psychiatrists is advisable in the assessment of poor growing children without recognizable organic causes, showing normal/high GH levels and low IGF-1 values.
KW - growth
KW - growth hormone
KW - IGF-1
KW - infantile anorexia nervosa
KW - prepubertal eating disorders
UR - http://www.scopus.com/inward/record.url?scp=84941057253&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84941057253&partnerID=8YFLogxK
U2 - 10.1515/jpem-2013-0400
DO - 10.1515/jpem-2013-0400
M3 - Article
C2 - 25153569
AN - SCOPUS:84941057253
VL - 28
SP - 999
EP - 1001
JO - Journal of Pediatric Endocrinology and Metabolism
JF - Journal of Pediatric Endocrinology and Metabolism
SN - 0334-018X
IS - 9-10
ER -