Growth in patients after allogeneic bone marrow transplant for hematological diseases in childhood

A. Cohen, M. T. Van-Lint, C. Uderzo, A. Rovelli, A. Lavagetto, V. Vitale, A. Morchio, A. Locasciulli, A. Bacigalupo, C. Romano

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The growth of 66 long-term survivors, transplanted in two centres (Genoa S. Martino and Monza) is reported. Patients were all under age 15 at the time of bone marrow transplantation (mean 9.8 ± 3.4 years; range 1.07-15 years) with a minimum follow-up of at least 12 months. They were divided into four groups. Group 1: eight patients with severe aplastic anemia (SAA); conditioning included cyclophosphamide (CY) 200 mg/kg only. Group 2: 32 patients with acute lymphoblastic leukemia (ALL), and acute myeloid leukemia (AML); conditioning included CY 120 mg/kg and 10-12 Gy fractionated total body irradiation (fTBI). Group 3: 20 patients with ALL who had previously received cranial irradiation; conditioning included CY 120 mg/kg and fTBI with an additional testicular irradiation (4 Gy). Group 4: six patients with chronic myeloid leukemia (CML) and AML; conditioning included CY 200 mg/kg and busulfan (BU) 16 mg/kg. Growth was impaired in all four groups, including the unirradiated groups (-0.2 ± 0.7 and -0.5 ± 0.6 delta-SDS in groups 1 and 4, respectively). Growth impairment-SDS was statistically significant in the two irradiated groups (-0.7 ± 1.0 and -0.9 ± 1.0 delta-SDS in groups 2 and 3, respectively), more marked in patients who had had previous cranial irradiation. Chronic graft-versus-host disease and its treatment were not found to have a major effect on growth.

Original languageEnglish
Pages (from-to)343-348
Number of pages6
JournalBone Marrow Transplantation
Issue number3
Publication statusPublished - 1995


  • Childhood
  • Growth
  • Hematological disease
  • Transplantation

ASJC Scopus subject areas

  • Hematology
  • Transplantation


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