Cranial irradiation is accompanied by a high incidence of hypopituitarism (1,2). Growth hormone (GH) deficiency is the earliest and often the only endocrine abnormality which occurs in patients treated with cerebral irradiation (2,3). An impaired GH response to pharmacological stimulation (4,5) or a blunted spontaneous pulsatile GH secretion (6) have been reported in children after cranial radiation. Moreover, leukemic patients given prophylactic cranial irradiation usually exhibit a significantly lower growth rate than those not receiving such treatment (7,8). Several studies in children undergoing bone marrow transplantation (BMT) for hematological diseases have demonstrated that long-term endocrine side effects are mainly related to the conditioning regimens including total body irradiation (TBI). Both hypothalamus and hypophysis may be directly damaged by irradiation. Moreover, differences in the vulnerability of the hypothalamic-pituitary axis to radiation damage and in variability in the timing of GH deficiency may exist. The aim of the present. work was to study growth and growth hormone (GH) secretion after BMT in two separate groups of our survivor patients. We only analyzed prepubertal children to avoid the interference of steroid hormones involved in the pubertal growth spurt.
|Number of pages||1|
|Journal||Bone Marrow Transplantation|
|Issue number||SUPPL. 1|
|Publication status||Published - 1991|
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