Growth in young children with chronic renal failure

Aldo Claris-Appiani, Maria L. Bianchi, Paolo Bini, Giorgio Ballabio, Maria P. Caraceni, Caterina Funari, Fabiola Terzi, Lucia Romeo, Roberto Rusconi

Research output: Contribution to journalArticlepeer-review

Abstract

Statural growth and its relation to growth potential, renal function, blood urea nitrogen (BUN), mineral metabolism hormones and dietary intake were studied in 17 prepubertal children (aged 1.6-9.3 years) on conservative treatment for chronic renal failure due to tubulo-interstitial nephropathy. Statural growth (height SDS) was related to the degree of renal failure, was more retarded than ossification, and was independent of the chronological age of the patients. We observed that the lower the glomerular filtration rate (GRF), the lower was the growth potential (increased bone age/statural age ratio). Growth velocity may be normal regardless of statural and bone maturation delay and the degree of renal insufficiency. Impaired growth rate correlated with parathyroid hormone levels, caloric intake and increased blood urea nitrogen during the year of observation. These data show that comprehensive monitoring and suitable treatment must be performed in order to prevent growth retardation at any GFR level.

Original languageEnglish
Pages (from-to)301-304
Number of pages4
JournalPediatric Nephrology
Volume3
Issue number3
DOIs
Publication statusPublished - Sep 1989

Keywords

  • Children
  • Chronic renal failure
  • Growth
  • Growth velocity

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology

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