Growth inhibition and induction of specific hepatic phenotype expression by retinoic acid in HEPG2 cells

Laura Falasca, Pierina Marcellini, Carmen Ara, Anna Rufo, Laura Conti Devirgiliis

Research output: Contribution to journalArticlepeer-review

Abstract

Retinoic acid, the active metabolite vitamin A, plays a role in the growth and differentiation of a variety of normal and malignant cells. In response to 5 μM retinoic acid the human hepatoma-derived cell line HepG2 underwent significant growth inhibition (not associated with cell death), which reached a level of 80% in comparison with controls, after 12 days of continuous treatment. Retinoic acid also induced morphological changes in these cells, in particular the development of canalicular-like structures, indicating progression to a more differentiated phenotype. In addition, a reduced expression of α-fetoprotein was found. We suggest that our results may be important for the design of novel therapeutic approaches using RA for the treatment of liver tumors.

Original languageEnglish
Pages (from-to)3283-3292
Number of pages10
JournalAnticancer Research
Volume19
Issue number4 B
Publication statusPublished - 1999

Keywords

  • Differentiation
  • HepG2
  • Proliferation
  • Retinoic acid

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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