Growth of infants with IgE-mediated cow's milk allergy fed different formulas in the complementary feeding period

Carlo Agostoni, Alessandro Fiocchi, Enrica Riva, Luigi Terracciano, Teresita Sarratud, Alberto Martelli, Fabio Lodi, Enza D'Auria, Gianvincenzo Zuccotti, Marcello Giovannini

Research output: Contribution to journalArticlepeer-review


Observational studies have shown that allergic infants, irrespective of the type of diet, show various degrees of growth depression in the first year of life. We investigated whether the type of milk in the complementary feeding period (6-12 months of age) is associated with differences in the increase of standardized growth indices (weight-for-age, WA; length-for-age, LA; and weight-for-length, WL, z-scores) in infants with cow's milk allergy (CMA). Infants with immunoglobulin E-mediated CMA breastfed at least 4 months and progressively weaned in the 5- to 6-month period were randomly assigned to three special formulas, a soy formula (n = 32), a casein hydrolysate (n = 31), and a rice hydrolysate (n = 30). A fourth, non-randomized group was made up by allergic infants still breastfed up to 12 months (n = 32). Groups were compared for WA, LA, and WL z-scores at 6, 9 and 12 months of age. All groups showed low WA and LA z-scores at 6 months of age. Infants fed hydrolyzed products showed a trend toward higher WA z-score increments in the 6- to 12-month period. The use of casein- and rice-based hydrolyzed formulas resulted in higher changes in WA compared with soy formula. Further research should be aimed at optimizing the dietary needs and feeding regimens for infants with CMA.

Original languageEnglish
Pages (from-to)599-606
Number of pages8
JournalPediatric Allergy and Immunology
Issue number7
Publication statusPublished - Nov 2007


  • Cow's milk allergy
  • Hydrolysate formula
  • Infants' growth
  • Soy formula

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pediatrics, Perinatology, and Child Health
  • Immunology


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